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Esophageal motility may be assessed using manometric techniques They are indicated (1) to determine the location of the lower esophageal sphincter to allow precise placement of a conventional electrode pH probe; (2) to establish the etiology of dysphagia in patients in whom a mechanical obstruction cannot be found, especially if a diagnosis of achalasia is suspected by endoscopy or barium study; (3) for the preoperative assessment of patients being considered for antireflux surgery to exclude an alternative diagnosis (eg, achalasia) or possibly to assess peristaltic function in the esophageal body



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The pH within the esophageal lumen may be monitored continuously for 24 48 hours There are two kinds of systems in use: catheter-based and wireless Traditional systems use a long transnasal catheter that is connected directly to the recording device Wireless systems are increasingly used; in these systems, a capsule is attached directly to the esophageal mucosa under endoscopic visualization and data are transmitted by radiotelemetry to the recording device The recording provides information about the amount of esophageal acid reflux and the temporal correlations between symptoms and reflux Esophageal pH monitoring devices provide information about the amount of esophageal acid reflux but not nonacid reflux New techniques using multichannel intraluminal impedance allow assessment of gas and nonacid liquid reflux Although not yet widely available, they may be useful in evaluation of patients with atypical reflux symptoms or persistent symptoms despite therapy





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The subtransient, transient, and steady-state fault currents are given in per-unit above The actual fault currents are found by multiplying by the base current in Region 2:

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Achem SR et al Dysphagia in aging J Clin Gastroenterol 2005 May Jun;39(5):357 71 [PMID: 15815202] Arora AS Management strategies for dysphagia with a normalappearing esophagus Clin Gastroenterol Hepatol 2005 Mar; 3(3):299 302 [PMID: 15765451] Bredenoord AJ et al Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy Am J Gastroenterol 2006 Mar;101(3):453 9 [PMID: 16464226] Hirano I Review article: modern technology in the diagnosis of gastro-oesophageal reflux disease Bilitec, intraluminal impedance and Bravo capsule pH monitoring Aliment Pharmacol Ther 2006 Mar;23 Suppl 1:12 24 [PMID: 16483266] Pandolfino JE et al; American Gastroenterological Association American Gastroenterological Association medical position statement: Clinical use of esophageal manometry Gastroenterology 2005 Jan;128(1):207 8 [PMID: 15633137] Pandolfino JE et al; American Gastroenterological Association AGA Technical review on the clinical use of esophageal manometry Gastroenterology 2005 Jan;128(1):209 24 [PMID: 15633138] Prakash C et al Value of extended recording time with wireless pH monitoring in evaluating gastroesophageal reflux disease Clin Gastroenterol Hepatol 2005 Apr;3(4):329 34 [PMID: 15822037]

Odynophagia is sharp substernal pain on swallowing that may limit oral intake It usually reflects severe erosive disease It is most commonly associated with infectious esophagitis due to Candida, herpesviruses, or CMV, especially in immunocompromised patients It may also be caused by corrosive injury due to caustic ingestions and by pill-induced ulcers

Endoscopy is the study of choice for evaluating persistent heartburn, odynophagia, and structural abnormalities detected on barium esophagography In addition to direct visualization, it allows biopsy of mucosal abnormalities and dilation of strictures

Patients with esophageal dysphagia often are evaluated first with a radiographic barium study to differentiate between mechanical lesions and motility disorders, providing important information about the latter in particular In patients with esophageal dysphagia and a suspected motility disorder, barium esophagoscopy should be obtained first In patients in whom there is a high suspicion of a mechanical lesion, many clinicians will proceed first to endoscopic evaluation because it better identifies mucosa lesions (eg, erosions) and permits mucosal biopsy and dilation However, barium study is more

Acid refluxate normally is cleared and neutralized by esophageal peristalsis and salivary bicarbonate During sleep, swallowing-induced peristalsis is infrequent, prolonging acid exposure to the esophagus One-third of patients with severe gastroesophageal reflux disease also have diminished peristaltic clearance Certain medical conditions such as scleroderma are associated with diminished peristalsis Sj gren s syndrome, anticholinergic medications, and oral radiation therapy may exacerbate gastroesophageal reflux disease due to impaired salivation

EXAM TIP Running the networking commands several times will help you memorize the functions of the commands as well as the syntax The CompTIA Network+ exam is big on the switches available for various commands, such as ipconfig /all

Heartburn; may be exacerbated by meals, bending, or recumbency Typical uncomplicated cases do not require diagnostic studies Endoscopy demonstrates abnormalities in < 50% of patients Barium esophagography seldom helpful

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