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Several parameters are utilized when assessing primary hepatocyte stabilization in vitro. For example, the presence in culture of the classic hepatocyte morphology including a cuboidal shape and well-de ned cell borders with intact bile canaliculi is considered suggestive of a mature stable phenotype. Furthermore, there are four categories of liver function: metabolism, synthesis, bile excretion, and detoxi cation (phase I and phase II). Speci c markers are frequently analyzed as surrogate measures of these processes in hepatocytes within various in vitro contexts. These include albumin secretion, urea synthesis, and cytochrome P-450 (phase I) activity [Bhatia et al., 1999]. In addition to being surrogate markers, each of these functions represents an important hepatocyte process, and, accordingly, each is a critical component of a potentially effective bioarti cial liver device. Although not measured routinely in our laboratory, assays for bile duct excretion and phase II activity have also been performed in our laboratory as well as others to assess the degree of hepatocyte stabilization. Also, when comprehensive analysis is required, microarray analysis of the expression of a broad range of functionally important genes can be utilized. In addition to the evaluation of isolated hepatocyte populations, the measurement of hepatocyte-speci c functions is important in the assessment of hepatocyte differentiation from stem cell sources such as embryonic



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Combo boxes can be inserted into command bar controls using the function CommandBar_InsertComboBox: CommandBar_InsertComboBox(hwndCB, hInst, iWidth, dwStyle, idComboBox, iButton); hwndCB and hInst are the same as with the other command bar functions we ve seen. iWidth specifies the width, in pixels, of the combo box control to be inserted. dwStyle defines the style of the combo box. This value can be one or more of the styles used for other combo box controls. idComboBox is the control identifier of the combo box, and iButton specifies where to put the control. If CommandBar_InsertComboBox is successful, it returns the HWND of the combo box that is created. If the function fails, the return value is NULL. Applications interact with combo boxes in command bars just as they do with other combo box controls. All messages and notifications that are generated by a command bar combo box are sent to the command bar control s parent window. The application s main window procedure therefore handles these events in its WM_COMMAND handler.





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H (Z1 , Z2 , . . . , ZK , K)

= (1m 2 + I\mm)[(A + X) 0 1m].

Aggregate the data into a single binary value. A Boolean (i.e., true or false) value would be suf cient to indicate if an animal was detected or not. Aggregate the data readings into an area. Coordinates of a bounding box can be given that de nes the area where the sensor readings are observed. Nodes,

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Oughts, in contrast, are de ned by a sense of duty, responsibility, or obligation. An ought is a self that one feels compelled to be, rather than intrinsically desires to be. The ought self is a positive value, in the sense that people try to conform to it. However, living up to an ought also implies acting to avoid a punishment self-disapproval or the disapproval of others. In our view, oughts are more complex structurally than ideals. Oughts intrinsically imply both an avoidance process and an approach process. Their structure thus resembles what was illustrated earlier in Figure 8.2. Recent work has demonstrated the avoidance aspect of the dynamics behind the ought self (Carver, Lawrence, & Scheier, 1999; Higgins & Tykocinski, 1992). A similar theme can be seen in the literature of selfdetermination theory (e.g., Deci & Ryan, 1985, 2000; Ryan & Deci, 2000). That theory focuses on the importance of having a sense of self-determination in one s actions. Actions that are self-determined are engaged in because they are of intrinsic interest or because they re ect values that are incorporated within the self. Such behavior clearly represents a voluntary approach of positive goal values. In contrast to this is what is termed controlled behavior, meaning that the behavior occurs in response to some sort of coercive force. The coercion can be from outside, or it can be self-coercion. An illustration of the latter is doing something because you feel you have to do it in order not to feel guilty. Such introjected values are very similar to the oughts of self-discrepancy theory, and we have suggested that they similarly involve an avoidance process along with the approach (Carver & Scheier, 1999a, 2000).

LOCK TABLE table_name IN EXCLUSIVE MODE;

(19)

Condensed Income Statement Year Ending Dec. 31, 0004 Revenue Expenses Net income $ 45,000 ( 33,000) $ 12,000

Figure 13a) or the rock surfaces which comprise the walls of a fracture (cf Figure 13b) Because of this pressure, the width of each pore tends to be slightly greater when the water is under high pressure than when the water is at low pressure Even more subtly, under very high pressures the water itself will compress slightly, such that the same mass of water will occupy a smaller volume than it will at lower pressures As the water pressure in a con ned aquifer drops (due to pumping perhaps) water levels in wells penetrating the aquifer will decline, the pores will contract, and the water itself will expand slightly Thus even though all of the pores remain completely lled with water, some water has been removed from storage due to compaction of the aquifer framework (ie.

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