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CMV infection can be discontinued in persons with durable suppression of viral load on HAART who have a CD4 count > 100 150 cells/mcL Similar results have been observed in patients with M avium complex bacteremia Prophylaxis for Pneumocystis pneumonia is also commonly discontinued in patients who have achieved and maintained a CD4 > 200 cells/mcL with good virologic control Treating patients with repeated episodes of the same opportunistic infection can pose difficult therapeutic challenges For example, patients with second or third episodes of Pneumocystis pneumonia may have developed allergic reactions to standard treatments with a prior episode Fortunately, there are several alternatives available for the treatment of Pneumocystis infection Trimethoprim with dapsone and primaquine with clindamycin are two combinations that often are tolerated in patients with a prior allergic reaction to trimethoprim-sulfamethoxazole and intravenous pentamidine On the positive side, patients in whom second episodes of Pneumocystis pneumonia develop while taking prophylaxis tend to have milder courses Well-established alternative regimens now also exist for most AIDS-related opportunistic infections: amphotericin B or fluconazole for cryptococcal meningitis; ganciclovir, cidofovir, or foscarnet for CMV infection; and sulfadiazine or clindamycin with pyrimethamine for toxoplasmosis Although conceptually it would seem that corticosteroid therapy should be avoided in HIV-infected patients, corticosteroid use has been shown to improve the course of patients



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The availability of agents that in combination suppress HIV replication (Table 31 5) has had a profound impact on the natural history of HIV infection Patients who achieve excellent suppression of HIV generally have stabilization or improvement of their clinical course that results from partial immunologic reconstitution and a subsequent decrease in AIDS-related complications The best time to initiate antiretroviral treatment remains controversial It is best to weigh the benefits of viral suppression against the side effects of the drugs for each patient In general, treatment should be initiated for asymptomatic HIV disease when the CD4 cell count drops below 350 cells/mcL or for symptomatic HIV disease Patients with rapidly dropping CD4 counts or very high viral loads (> 100,000/mcL) should be considered for earlier treatment For those patients who might have difficulty adhering to treatment or who are at higher risk for toxicity (eg, underlying liver disease), waiting until the CD4 count nears 200 cells/mcL may be a better strategy Patients who started receiving treatment at higher CD4 levels than are currently recommended for initiation of treatment are usually maintained on their regimens if they are doing well and are not





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Nucleoside reverse transcriptase inhibitors Zidovudine (AZT) (Retrovir) 600 mg orally daily in two divided doses Anemia, neutropenia, nausea, malaise, headache, insomnia, myopathy Peripheral neuropathy, pancreatitis, dry mouth, hepatitis Peripheral neuropathy, aphthous ulcers, hepatitis Peripheral neuropathy, hepatitis, pancreatitis Rash, peripheral neuropathy Skin discoloration palms/soles (mild) Rash, fever if occur, rechallenge may be fatal No special monitoring $602/300 mg $36097

Didanosine (ddI) (Videx)

400 mg orally daily (enteric-coated capsule) for persons 60 kg 0375 075 mg orally three times daily 40 mg orally twice daily for persons 60 kg 150 mg orally twice daily 200 mg orally once daily 300 mg orally twice daily

This machine is now connected as a cumulatively compounded dc motor with Radj = 120 (a) What is the full-load speed of this motor (b) Plot the torque-speed characteristic for this motor (c) What is its speed regulation SOLUTION (a) At full load, I A = I L I F = 100 A - 075 A = 9925 A , and

Bimonthly neurologic questionnaire for neuropathy, K+, amylase, bilirubin, triglycerides Monthly neurologic questionnaire for neuropathy Monthly neurologic questionnaire for neuropathy, amylase No special monitoring No special monitoring No special monitoring

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Successful implementation of a basic structured cabling network requires three essential ingredients: a telecommunications room, horizontal cabling, and a work area Let s zero in on one floor of Figure 5-12 from the previous chapter All the cabling runs from individual PCs to a central location, the telecommunications room (Figure 6-4) What equipment goes in there a switch or a telephone system is not the important thing What matters is that all the cables concentrate in this one area

$31140

Zalcitabine (ddC) (Hivid) Stavudine (d4T) (Zerit) Lamivudine (3TC) (Epivir) Emtricitabine (Emtriva) Abacavir (Ziagen)

$24570

$37044

(continued )

This field current would produce a voltage E Ao of 288 V at a speed of no = 1800 r/min The actual E A is 240 V, so the actual speed at full load will be

Table 31 5 Antiretroviral therapy (continued)

All cables run horizontally (for the most part) from the telecommunications room to the PCs This cabling is called, appropriately, horizontal cabling A single piece of installed horizontal cabling is called a run At the opposite end of the horizontal cabling from the telecommunications room is the work area The work area is often simply an office or cubicle that potentially contains a PC and a telephone Figure 6-5 shows both the horizontal cabling and work areas Each of the three parts of a basic star network the telecommunications room, the horizontal cabling, and the work area(s) must follow a series of strict standards

Drug Tenofovir (Viread) Saquinavir hard gel (Invirase) Ritonavir (Norvir) Dose 300 mg orally once daily Common Side Effects Gastrointestinal distress Gastrointestinal distress Gastrointestinal distress, peripheral paresthesias Special Monitoring1 Renal function Cost2 $1930/300 mg Cost/Month $57900

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