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Bytescout PDF Generator SDK for Javascript that can also run on Android, iOS browsers and can generate PDFs with text with font formatting, links, tables, and ... achieved, usually 20 40 mg four times daily Doses as high as 80 mg four times daily are occasionally required A long-acting (LA) propranolol formulation provides more consistent relief; doses are 60, 80, 120, and 160 mg Propranolol LA is initially given every 12 hours for patients with severe hyperthyroidism, due to accelerated metabolism of the propranolol; it may be given once daily as hyperthyroidism improves 2 Thiourea drugs Methimazole or propylthiouracil is generally used for young adults or patients with mild thyrotoxicosis, small goiters, or fear of isotopes Carbimazole is another thiourea, available outside the United States, that is converted to methimazole in vivo Elderly patients usually respond particularly well Thiourea drugs may be administered long-term These drugs are also useful for preparing hyperthyroid patients for surgery and elderly patients for RAI treatment The drugs do not permanently damage the thyroid and are associated with a lower chance of posttreatment hypothyroidism (compared with RAI or surgery) When thiourea therapy is discontinued, there is a high recurrence rate for hyperthyroidism (about 50%) A better likelihood of long-term remission is seen in patients with small goiters or mild hyperthyroidism and those requiring small doses of thiourea Patients whose thyroperoxidase and thyroglobulin antibodies remain high after 2 years of therapy have been reported to have only a 10% rate of relapse Thiourea therapy may be continued long-term for patients who are tolerating it well Agranulocytosis occurs in about 03% of patients taking methimazole and about 04% of patients taking propylthiouracil Agranulocytosis usually occurs in the first 60 days of therapy, and it develops in a few patients after 5 months of therapy There is a genetic tendency to develop agranulocytosis with thiourea therapy; if a close relative has had this adverse reaction, other therapies should be considered for the patient Patients are warned that if a sore throat or febrile illness develops, they should stop the drug while a WBC is rechecked The agranulocytosis is generally reversible; recovery is not improved by filgrastim (granulocyte colony-stimulating factor [G-CSF]) Periodic surveillance of the WBC during treatment has been advocated, but the onset of agranulocytosis is generally abrupt Other side effects common to thiourea drugs include pruritus, allergic dermatitis, nausea, and dyspepsia Antihistamines may control mild pruritus without discontinuation of the drug Since the two thiourea drugs are similar, patients who have had a major allergic reaction from one should not be given the other Primary hypothyroidism may occur The patient may become clinically hypothyroid for 2 weeks or more before TSH levels rise, having been suppressed by the preceding hyperthyroidism Therefore, the patient s changing thyroid status is best monitored clinically and with serum levels of FT4 Rapid growth of the goiter usually occurs if prolonged hypothyroidism is allowed to develop; the goiter may sometimes become massive but usually regresses rapidly with thyroid hormone replacement a Methimazole Methimazole has the advantage of requiring less frequent dosing and fewer pills than propylthiouracil Patients treated with methimazole (compared. javascript code to convert pdf to word: How To: Converting PDF to Word and HTML - Geedew - Blogging ... javascript pdf generator client side Save base64 string as PDF at client side with JavaScript - Stack ...
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