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fatty acyl-CoA is reduced by an NADPH-dependent reductase to the trans-3-R CH2 CH CH CH2 C( O) S CoA The 3-trans double bond is then isomerized to the 2-trans double bond, and oxidation proceeds as normal If you count ATPs by this pathway, each double bond at an even carbon would decrease the yield of ATP by 5 (assuming that the NADPH used is equivalent to NADH and would produce 3 ATPs if oxidized by the electron transport chain and that no FADH2 is made in putting in the double bond)

Mn/2



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Makes propionyl-CoA, which is metabolized by propionyl-CoA carboxylase (biotin) and methylmalonyl-CoA mutase (B12) to give succinyl-CoA Since there s no good way to make a C-1 fragment during oxidation, the metabolism of fatty acids with an odd number of carbons must finally give you a 3-carbon piece as propionyl-CoA Odd-chain-length fatty acids aren t very abundant in nature (some shellfish and bacteria make odd-chain-length fatty acids), but they may be somewhat more common on exams The propionyl-CoA resulting from the oxidation of odd-chain fatty acids is metabolized by a weird pathway that is also used to metabolize the propionyl-CoA produced by the breakdown of the amino acid threonine Two vitamins are required in this pathway, biotin and B12 This is one of two places you ll see vitamin B12 (the other is in the metabolism of 1-carbon fragments; see Fig 13-7)

Parameters for the Properties Pane Web Item (continued)





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In short, the product of Mn ( ) with vector (a0 , , an 1 ), a size-n problem, can be expressed in terms of two size-n/2 problems: the product of M n/2 ( 2 ) with (a0 , a2 , , an 2 ) and with (a1 , a3 , , an 1 ) This divide-and-conquer strategy leads to the de nitive FFT algorithm of Figure 29, whose running time is T (n) = 2T (n/2) + O(n) = O(n log n)

SCoA O propionyl-CoA ATP biotin CO2 propionyl-CoA carboxylase CO2O methyl-malonyl-CoA methyl-malonyl-CoA mutase O -O2C succinyl-CoA SCoA B12

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The fast Fourier transform unraveled Throughout all our discussions so far, the fast Fourier transform has remained tightly cocooned within a divide-and-conquer formalism To fully expose its structure, we now unravel the recursion The divide-and-conquer step of the FFT can be drawn as a very simple circuit Here is how a problem of size n is reduced to two subproblems of size n/2 (for clarity, one pair of outputs (j, j + n/2) is singled out): 71

Figure 13-7

FFTn/2

Metabolism of ODD-CHAIN-LENGTH FATTY ACIDS yields propionylCoA, which can be rearranged to succinyl-CoA and dumped into the TCA cycle

Table 4-29 lists and describes the parameters for the Ticker Web item, arranged according to the various parameter groupings

FFTn/2

Oxidation and Reduction The Electron Transport Chain Connections Regulation P/O Ratios Uncouplers Inhibitors

application and to specify which context menu choices are available to the user of the Web application If you do not drag the Web item onto the Web template and make your settings, the standard context menu is displayed in the Web application The following illustration shows this Web item in the system This has replaced the option in the older version for the Basic Context Menu items versus the Advanced Context Menu list This only has the option to turn the item on or off, not to have enhanced and basic context menus The alternative to having an Enhanced and Basic Menu would be to use some functionality via the Menu Bar Web item

You only have to look at the ATP yield from the TCA cycle, 12 of them per molecule of acetyl-CoA, to know that oxidative phosphorylation must be important That s where all the electrons from NADH and FADH2 go after they re made by the TCA cycle

j + n/2

4:

Oxidation is the loss of electrons NADH is oxidized to NAD Reduction is the gain of electrons O2 is reduced to H2O Electrons usually aren t floating around in space; they re stuck on some atom or other The simple consequence of this is that when one

rj+n/2

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