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Nematodes of rats of the genus Angiostrongylus cause two distinct syndromes in humans Angiostrongylus cantonensis, the rat lungworm, causes eosinophilic meningoencephalitis, primarily in southeast Asia and some Pacific islands Angiostrongylus costaricensis causes gastrointestinal inflammation In both diseases, human infection follows ingestion of larvae within slugs or snails (and also crabs or prawns for A cantonensis) or on material contaminated by these organisms Since the parasites are not in their natural hosts, they cannot complete their life cycles, but they can cause disease after migrating to the brain or gastrointestinal tract In A cantonensis infection, disease appears to be caused primarily by worm larvae migrating through the CNS and an inflammatory response to dying worms After an incubation period of 1 day to 2 weeks, presenting symptoms and signs include headache, stiff neck, nausea, vomiting, cranial nerve abnormalities, and paresthesias Most cases resolve spontaneously after 2 8 weeks, but serious sequelae and death have been reported The diagnosis is strongly suggested by the finding of eosinophilic CSF pleocytosis (leukocytosis with over 10% eosinophils) in a patient with a history of travel to an endemic area Peripheral eosinophilia may not be present A cantonensis larvae have rarely been recovered from the CSF and the eyes There is no specific treatment Antihelminthic therapy is probably not indicated, since responses to dying worms may worsen with therapy Corticosteroids have been used in severe cases In A costaricensis infection, parasites penetrate ileocecal vasculature and develop into adults, which lay eggs, but do not complete their life cycle Disease is due to an inflammatory response to dying worms in the intestinal tract, with an eosinophilic granulomatous response, at times including vasculitis and ischemic necrosis Common findings are abdominal pain, vomiting, and fever Pain is most commonly localized to the right lower quadrant, and a mass may be appreciated, all mimicking appendicitis Symptoms may recur over months Uncommon findings are intestinal perforation or obstruction, or disease due to migration of worms to other sites Many cases are managed surgically, usually for suspected appendicitis Biopsy of inflamed intestinal tissue may show worms localized to mesenteric arteries.



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The clinical diagnosis is supported by findings of elevated serum muscle enzymes (creatine kinase, lactate dehydrogenase, aspartate aminotransferase) Serologic tests become positive 3 or more weeks after infection; a variety of techniques are used, including ELISA, immunofluorescence, indirect hemagglutinin, precipitin, and bentonite flocculation assays Rising antibody titers are highly suggestive of the diagnosis Muscle biopsy can usually be avoided, but if the diagnosis is uncertain, biopsy of a tender, swollen muscle may identify Trichinella larvae For maximal yield, biopsy material should be examined histologically, and a portion should be enzymatically digested to release larvae, but evaluation before about 3 weeks after infection may not show muscle larvae

No effective specific therapy for full-blown trichinosis has been identified However, if infection is suspected early in the course of illness, treatment with mebendazole (25 mg/kg twice daily) or albendazole (5 75 mg/kg twice daily) will kill





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and eosinophilic granulomas It is not known if antihelminthic therapy is helpful, but diethylcarbamazine, thiabendazole, and mebendazole have been used

j0233 00465

Figure 7-34

Lai CH et al Eosinophilic meningitis caused by Angiostrongylus cantonensis after ingestion of raw frogs Am J Trop Med Hyg 2007 Feb;76(2):399 402 [PMID: 17297055] Mentz MB et al Drug trials for treatment of human angiostrongyliasis Rev Inst Med Trop Sao Paulo 2003 Jul Aug;45 (4):179 84 [PMID: 14502343] Tsai HC et al Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan Am J Trop Med Hyg 2004 Aug;71(2):222 6 [PMID: 15306715]

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The dog roundworm Toxocara canis, the cat roundworm Toxocara cati, and less commonly other helminths may cause visceral larva migrans T canis is highly prevalent in dogs Humans are infected after ingestion of eggs in material contaminated by dog or other feces With T canis, infection is spread principally by puppies and lactating females, and the eggs must be on the ground for several weeks before they are infectious After ingestion by humans, larvae migrate to various tissues but cannot complete their life cycle Visceral larva migrans is seen principally in young children Most infections are asymptomatic The most commonly involved organs are the liver and lungs Presentations include cough, fever, wheezing, hepatomegaly, splenomegaly, lymphadenopathy, pulmonary infiltrates, and eosinophilia Involvement of the CNS can occur rarely, leading to eosinophilic meningitis and other abnormalities Ocular larva migrans is a distinct syndrome, usually in children older than is typical for visceral larva migrans Children present with visual deficits, pain, and a retinal mass, which can be confused with retinoblastoma Baylisascaris procyonis, a roundworm of raccoons, can rarely cause visceral larva migrans in humans, with typically more severe manifestations than those with T canis, including eosinophilic meningitis and eye disease The diagnosis of visceral larva migrans is suggested by the finding of eosinophilia in a child with hepatomegaly or other signs of the disease, especially with a history of exposure to puppies The diagnosis is confirmed by the identification of larvae in a biopsy of infected tissue, usually performed when other diseases are suspected Serologic tests may be helpful; an available ELISA was estimated to have 78% sensitivity and 92% specificity Most patients recover without specific therapy, although symptoms may persist for months Treatment with antihelminthics or corticosteroids may be considered in severe cases No drugs have been proven to be effective, but albendazole (400 mg twice daily for 5 days), mebendazole, thiabendazole, diethylcarbamazine, and ivermectin have been used, and albendazole has been recommended as the treatment of choice.

Despommier D Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects Clin Microbiol Rev 2003 Apr;16(2):265 72 [PMID: 12692098] Gavin PJ et al Baylisascariasis Clin Microbiol Rev 2005 Oct; 18(4):703 18 [PMID: 16223954] Good B et al Ocular toxocariasis in schoolchildren Clin Infect Dis 2004 Jul 15;39(2):173 8 [PMID: 15307025] Moreira-Silva SF et al Toxocariasis of the central nervous system: with report of two cases Rev Soc Bras Med Trop 2004 Mar Apr;37(2):169 74 [PMID: 15094904] Vidal JE et al Eosinophilic meningoencephalitis due to Toxocara canis: case report and review of the literature Am J Trop Med Hyg 2003 Sep;69(3):341 3 [PMID: 14628955]

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