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Tutorials, tools, scripts and samples for scripting Acrobat and PDF . ... Free Automation Tools · Automation Tool Descriptions · Free Sample Files ... AcroDialogs is a drag and drop graphical editor for creating Acrobat JavaScript Dialogs Boxes. For P vivax and P ovale infections, standard therapy includes chloroquine to eradicate erythrocytic forms and primaquine to eradicate liver hypnozoites and prevent a subsequent relapse Chloroquine is given for acute infection, and if the G6PD level is normal, a 14-day course of primaquine is then initiated Standard chemoprophylaxis does not prevent a relapse of P vivax or P ovale infections, since the hypnozoite forms of these parasites are not eradicated by chloroquine or other standard treatments To diminish the likelihood of relapse, some authorities advocate the use of primaquine after the completion of travel to an endemic area Primaquine has also been studied as a daily chemoprophylactic agent Daily treatment with 05 mg/kg of base (to a maximum of 30 mg/day) provides protection against malaria caused by P falciparum and P vivax, but should only be used in persons with documented normal levels of G6PD In addition, potential toxicities of long-term use remain a concern, and primaquine is not a first-line choice for this purpose Primaquine in recommended doses is generally well tolerated It infrequently causes nausea, epigastric pain, abdominal cramps, and headache, especially when taken on an empty stomach Rare adverse effects include leukopenia, agranulocytosis, leukocytosis, and cardiac arrhythmias Standard doses of primaquine may cause hemolysis or methemoglobinemia (manifested by cyanosis), especially in persons with G6PD deficiency or other hereditary metabolic defects Patients should be tested for G6PD deficiency before primaquine is prescribed When a patient is deficient in G6PD, treatment strategies may consist of (1) withholding therapy and treating subsequent relapses, if they occur, with chloroquine; (2) treating patients with standard dosing, paying close attention to their hematologic status; or (3) treating with weekly primaquine (45 mg base) for 8 weeks G6PD-deficient individuals of Mediterranean and Asian ancestry are most likely to have severe deficiency, while those of African ancestry usually have a milder biochemical defect This difference can be taken into consideration in choosing a treatment strategy Primaquine should be discontinued if there is evidence of hemolysis or anemia and should be avoided in pregnancy 6 Inhibitors of folate synthesis Inhibitors of two parasite enzymes involved in folate metabolism, dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), are used, generally in combination regimens, for the treatment and prevention of malaria These include the DHFR inhibitors pyrimethamine, proguanil, and chlorproguanil, and the DHPS inhibitors sulfadoxine and dapsone All described antifolates act slowly against erythrocytic forms of susceptible strains of all four human malaria species They are not reliably effective against hepatic stages or gametocytes Available fixed-dosed antifolate combinations to treat malaria are sulfadoxine-pyrimethamine (Fansidar) and chloroproguanil/ dapsone (Lapdap) These drugs will be discussed only as combinations, as they are not otherwise used to treat or prevent malaria Malarone, a combination of proguanil with atovaquone, is discussed below Fansidar is a fixed combination of sulfadoxine (500 mg) and pyrimethamine (25 mg) Its components reach peak plasma levels within 2 8 hours, with average half-lives of about. online pdf javascript editor: PDFObject: A JavaScript utility for embedding PDFs javascript pdf editor library Beautiful WYSIWYG HTML Editor | Javascript Rich Text Editor | Froala
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For basic editing, you may need to install a suitable Linux pdf editor because Linux does not come with a default pdf editor . 7 Artemisinins Artemisinin (qinghaosu) is a sesquiterpene lactone endoperoxide, the active component of an herbal medicine that has been used as an antipyretic in China for over 2000 years Analogs have been synthesized to increase solubility and improve antimalarial efficacy The most important of these analogs are artesunate, artemether, and dihydroartemisinin Artemisinin and its analogs are rapidly absorbed, with peak plasma levels occurring in 1 2 hours and half-lives of 1 3 hours after oral administration Artesunate and artemether are rapidly metabolized to the active metabolite dihydroartemisinin None of the artemisinins are available in the United States, but artemether and artesunate are widely available in other countries Artemisinin and analogs act very rapidly against all erythrocytic-stage human malaria parasites They have no effect on hepatic stages Artemisinin resistance is not yet an important problem, but P falciparum isolates with diminished in vitro susceptibility to artemether have recently been described The antimalarial activity of artemisinins may result from the production of free radicals that follows the iron-catalyzed cleavage of the artemisinin endoperoxide bridge in the parasite food vacuole or inhibition of a parasite calcium ATPase Artemisinins, in particular artesunate and artemether, are playing an increasing role in the treatment of malaria, including multidrug-resistant P falciparum malaria However, due to their short plasma half-lives, recrudescence rates are unacceptably high after short-course therapy, and they are best used in conjunction with another agent Also because of their short-half lives, they are not useful in chemoprophylaxis Artesunate and artemether are widely available in many countries for the treatment of uncomplicated and severe falciparum malaria, but they are much more expensive than older therapies Their use for uncomplicated malaria should be in combination regimens including a longer-acting partner drug Artesunate plus mefloquine has demonstrated excellent efficacy against multidrug resistant parasites in Thailand, but this regimen is too expensive for widespread use in Africa and other areas The aretemisinin-based combination regimens that are currently most advocated in Africa are artesunate plus amodiaquine and artemether plus lumefantrine (Coartem), both of which are now available as coformulated products Each of these combinations is now the recommended therapy for uncomplicated malaria in a number of countries in Africa, although implementation of new treatment guidelines has been slowed due to the high cost of the new therapies, limited drug availability, and other factors In a number of studies of severe malaria, artesunate and artemether were at least as effective as quinine, though mortality from severe malaria remained high Artesunate and artemether have also been effective in the treatment of severe malaria when administered rectally, offering a valuable treatment modality when parenteral therapy is not available Artemisinins appear to be better tolerated than most antimalarials The most commonly reported adverse effects have been nausea, vomiting, and diarrhea Irreversible neurotoxicity has been seen in animals, but only after doses much higher than those used to treat malaria, and this problem has not been recognized in humans after widespread use of the drugs Artemisinins should be avoided in pregnancy if possible because teratogenicity has been seen in animal studies, but. javascript wysiwyg pdf editor jsPDF - HTML5 PDF Generator | Parallax
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