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meter in length, are gradually extruded Worm death and disintegration in tissue may provoke a severe inflammatory reaction Patients are usually asymptomatic until the time of worm extrusion At that time a painful papule develops, with erythema, pruritus, and burning, usually on the lower leg Multiple lesions may be present At this time, some patients may also develop a short-lived systemic reaction, which may include fever, urticaria, nausea, vomiting, diarrhea, and dyspnea The skin lesion vesiculates over a few days, followed by ulceration The ulcer is tender, often with a visible worm The worm is then extruded or absorbed over a few weeks, followed by ulcer healing Secondary infections, including infectious arthritis and tetanus, are common The disease causes significant disability; lesions commonly prevent walking for a month or more Diagnosis follows identification of a typical skin ulcer with a protruding worm When the worm is not visible, larvae may be identified on smears or seen after immersion in cold water Eosinophilia is usually present No drug cures the infection, but metronidazole and mebendazole are sometimes used to limit inflammation and facilitate worm removal Wet compresses may relieve discomfort Occlusive dressings improve hygiene and limit shedding of infectious larvae Worms are typically removed by sequentially rolling them out over a small stick When available, simple surgical procedures can be used to remove worms Corticosteroid ointments may hasten healing Topical antibiotics may limit bacterial superinfection Dracunculiasis has proven to be easier to control than most parasitic infections The disease is prevented by avoidance of contaminated drinking water This can be accomplished by boiling, chlorination, or filtration through finely woven cloth A WHO dracunculiasis eradication program, initiated in 1986, has been highly successful



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Greenaway C Dracunculiasis (guinea worm disease) CMAJ 2004 Feb 17;170(4):495 500 [PMID: 14970098] Muller R Guinea worm disease the final chapter Trends Parasitol 2005 Nov;21(11):521 4 [PMID: 16150643] Ruiz-Tiben E et al Dracunculiasis (Guinea worm disease) eradication Adv Parasitol 2006;61:275 309 [PMID: 16735167]

Type Type 1 (A) Immune-mediated (B) Idiopathic Type 2 (A) Nonobese (B) Obese Absent Absent Absent Absent Negative Negative (1) Eucaloric diet alone (2) Diet plus insuline or oral agents (1) Weight reduction (2) Hypocaloric diet, plus oral agents or insulin Present Present Present at onset Absent Positive Absent Eucaloric healthy diet and preprandial rapidly acting insulin, plus basal insulin replacement with intermediate-acting or long-acting insulin Ketosis Islet Cell Antibodies HLA Association Treatment

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All transformers in this figure are Y- , and the base quantities are the same for all of them, so the per-unit transformer impedances are:





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varies among different racial groups with type 2 diabetes While obesity is apparent in no more than 30% of Chinese and Japanese patients with type 2, it is found in 60 70% of North Americans, Europeans, or Africans with type 2 and approaches 100% of patients with type 2 among Pima Indians or Pacific Islanders from Nauru or Samoa Visceral obesity, due to accumulation of fat in the omental and mesenteric regions, correlates with insulin resistance; subcutaneous abdominal fat seems to have less of an association with insulin insensitivity Exercise may affect the deposition of visceral fat as suggested by CT scans of Japanese wrestlers, whose extreme obesity is predominantly subcutaneous Their daily vigorous exercise program prevents accumulation of visceral fat, and they have normal serum lipids and euglycemia despite daily intakes of 5000 7000 kcal and development of massive subcutaneous obesity Several adipokines, secreted by fat cells, can affect insulin action in obesity Two of these, leptin and adiponectin, seem to increase sensitivity to insulin, presumably by increasing hepatic responsiveness Two others tumor necrosis factor- , which inactivates insulin receptors, and the newly discovered peptide, resistin interfere with insulin action on glucose metabolism and have been reported to be elevated in obese animal models Mutations or abnormal levels of these adipokines may contribute to the development of insulin resistance in human obesity Hyperglycemia per se can impair insulin action by causing accumulation of hexosamines in muscle and fat tissue and by inhibiting glucose transport (acquired glucose toxicity) Correction of hyperglycemia reverses this acquired insulin resistance

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Table 27 3 Diagnostic sensitivity and specificity of autoimmune markers in patients with newly diagnosed type 1 diabetes mellitus

Sensitivity Glutamic acid decarboxylase (GAD65) Insulin (IAA) Tyrosine phosphatase (IA-2) 70 90% 40 70% 50 70% Specificity 99% 99% 99%

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