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The onset is sudden, with high fever, malaise, tachycardia, intense headache, delirium, and severe myalgias The patient appears profoundly ill If pneumonia develops, tachypnea, productive cough, blood-tinged sputum, and cyanosis also occur There may be signs of meningitis A pustule or ulcer at the site of inoculation and lymphangitis may be observed Axillary, inguinal, or cervical lymph nodes become enlarged and tender and may suppurate and drain With hematogenous spread, the patient may rapidly become toxic and comatose, with purpuric spots (black plague) appearing on the skin Primary plague pneumonia is a fulminant pneumonitis with bloody, frothy sputum and sepsis It is usually fatal unless treatment is started within a few hours after onset



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2 Answers. In Acrobat, you can select Tools> JavaScript to edit document level scripts. For scripts that are associated with form fields, links, bookmarks, you need to edit the relevant element and then edit the action/validation/calculation/formatting scripts.

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Hematogenous spread may produce meningitis, perisplenitis, pericarditis, pneumonia, and osteomyelitis

+ NSE 600 V + NC 120 V -

Streptomycin is drug of choice for treatment of tularemia The recommended dose is 75 mg/kg intramuscularly every 12 hours for 7 14 days Gentamicin, which has good in vitro activity against F tularensis, is generally less toxic than streptomycin and probably just as effective Doxycycline (200 mg/d orally) is also effective but has a higher relapse rate A variety of other agents (eg, fluoroquinolones) are active in vitro but their clinical effectiveness is less well established

Hassoun A et al Tularemia and once-daily gentamicin Antimicrob Agents Chemother 2006 Feb;50(2):824 [PMID: 16436758] Staples JE et al Epidemiologic and molecular analysis of human tularemia, United States, 1964 2004 Emerg Infect Dis 2006 Jul;12(7):1113 8 [PMID: 16836829]

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The plague bacillus may be found in smears from aspirates of buboes examined with Gram stain Cultures from bubo aspirate or pus and blood are positive but may grow slowly In convalescing patients, an antibody titer rise may be demonstrated by agglutination tests

The lymphadenitis of plague is most commonly mistaken for the lymphadenitis accompanying staphylococcal or streptococcal infections of an extremity, sexually transmitted diseases such as lymphogranuloma venereum or syphilis, and tularemia The systemic manifestations resemble those of enteric or rickettsial fevers, malaria, or influenza The pneumonia resembles other bacterial pneumonias, and the meningitis is similar to those caused by other bacteria

History of exposure to rodents in endemic area Sudden onset of high fever, malaise, muscular pains, and prostration Axillary or inguinal lymphadenitis (bubo) Bacteremia, pneumonitis, and meningitis may occur Positive smear and culture from bubo and positive blood culture

The ABCD constants for this line are:

Drug prophylaxis may provide temporary protection for persons exposed to the risk of plague infection, particularly by the respiratory route Tetracycline hydrochloride, 500 mg orally once or twice daily for 5 days, is effective

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Hopding/pdf-lib: Create and modify PDF documents in any ... - GitHub
Support modification ( editing ) of existing documents. Work in all ... There are other good open source JavaScript PDF libraries available. However, most of them ...

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Plague vaccines both live and killed have been used for many years, but their efficacy is not clearly established

Therapy should be started immediately once plague is suspected Either streptomycin (the agent with which there is greatest experience), 1 g every 12 hours intravenously, or gentamicin, administered as a 2-mg/kg loading dose, then 17 mg/kg every 8 hours intravenously, is effective Alternatively, doxycycline, 100 mg orally or intravenously, may be used The duration of therapy is 10 days Patients with plague pneumonia are placed in strict respiratory isolation, and prophylactic therapy is given to any person who came in contact with the patient

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Centers for Disease Control and Prevention (CDC) Human plague four states, 2006 MMWR Morb Mortal Wkly Rep 2006 Sep 1;55(34):940 3 [PMID: 16943764]

Purulent and profuse urethral discharge, especially in men, with dysuria, yielding positive smear Epididymitis, prostatitis, periurethral inflammation, proctitis in men Cervicitis in women with purulent discharge, or asymptomatic, yielding positive culture; vaginitis, salpingitis, proctitis also occur Fever, rash, tenosynovitis, and arthritis with disseminated disease Gram-negative intracellular diplococci seen in a smear or cultured from any site, particularly the urethra, cervix, pharynx, and rectum

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PDFObject: A JavaScript utility for embedding PDFs
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