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Light adaptation is the decrease in visual sensitivity upon increases in the overall level of illumination. For example, it is easy to see millions of stars on a clear night. An equivalent number and variety of stars are present in the sky on a clear day; however, we are unable to perceive them. This is because the overall luminance level of the sky is several orders of magnitude higher in the daytime than at night. This causes visual sensitivity to changes in luminance to be reduced in the daytime relative to night. Thus the luminance change that served to produce the perception of millions of stars at night is inadequate to allow their perception during the day. As another example, imagine waking up in the middle of the night and switching on a bright room light. At rst your visual system is dazzled, you are unable to see much of anything, and you might even feel a little pain. Then, after tens of seconds, you begin to be able to view objects normally in the illuminated room. What has happened is that the mechanisms of vision were at their most sensitive in the dark room. When the light was rst switched on, they were overloaded due to their high sensitivity. After a short



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-2[q(w; {quad) - q(w;{cub)] -2(324.7168 - 324.8720) = 0.3104

(3.88)

You can quickly move to areas of your worksheet either by using the Name box, located at the left side of the Formula bar (click on the arrow to drop down a list of de ned names) or by choosing Home Editing Find & Select Go To (or F5) and specifying the range name. Creating formulas is easier. You can paste a cell or range name into a formula by using Formula AutoComplete. Names make your formulas more understandable and easier to use. A formula such as =Income-Taxes is more intuitive than =D20-D40.

BOD, COD, and Metals in Cotton Extracts [1]

planning horizon planning periods a a a a d a a d d a d a d d d d d time sets of arrivals and sets of departures





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the various time points during accelerated stability study and at intermediate storage conditions when they are used and evaluation of long-term stability data Different scenarios for retest period and shelf life determination are presented based on the results observed under accelerated, intermediate, and long-term storage conditions [11], as described below Long-Term and Accelerated Stability Data Show Little or No Change over Time and Little or No Variability The drug substance or drug product can be considered stable if the long-term and accelerated stability data show little or no change or little no variability over time In this scenario, no statistical analysis is required but a justi cation should include a discussion of the pattern of change or variability or lack of change or variability, supportive accelerated stability data, mass balance of drug substance in samples, and/or other supporting data.

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nation were, from the fourteenth or fteenth century onwards, formed in our secondary schools, we shall, as we progress, be driven to what almost amounts to writing a history of the French intellectual. It is additionally true that this disproportionate role played by secondary education in the totality of that social life which is peculiar to our nation and which is not to be found anywhere else to the same extent, will, as we can be sure in advance, derive from some personally distinctive characteristic, some idiosyncrasy in our national temperament which we shall come to uncover simply because we shall be seeking the causes of this peculiarity in the history of our educational thought. The history of educational thought and the study of social mores are indeed closely linked. . . .

The retest period or shelf life in this scenario can be up to twice as long as but not more than 12 months beyond the period covered by long-term storage stability data However, extrapolation of the retest period or shelf life beyond the period covered by long-term data can be proposed Long-Term and Accelerated Stability Data Show Change over Time and/or Variability In this scenario, statistical analysis of the long-term data can be useful in establishing a retest period or shelf life When there are differences, for example, among batches or among dosage strengths, container sizes, and/or ll or any combination thereof that preclude combining the data, the proposed retest date or shelf life should not exceed the shortest period supported by long-term studies of any batch, other factors, or combinations of factors.

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