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However, when differences are attributed, for example, to strength of the dosage form, different shelf lives can be assigned to different strengths within the dosage form of the drug product, with appropriate discussion of the data generated If the statistical analysis is performed on long-term data and the statistical and other relevant data are supportive, it can be appropriate to extrapolate and propose a retest period or shelf life up to twice as long but not more than 12 months beyond the period covered by long-term storage stability data When long-term stability data are not amenable to statistical analysis, the proposed retest period or shelf life can be up to one and a half as long as but not more than 6 months beyond the period covered by long-term data.



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Accelerated Stability Data Show Signi cant Change When a signi cant change occurs at the accelerated storage condition, stability results at the intermediate condition and the long-tem storage condition will determine the retest period or shelf life The guidance [11] suggests two exceptions to the observations at accelerated conditions: (1) physical change such as softening of a suppository designed to melt at 37 C if the melting point is clearly demonstrated and (2) failure to meet acceptance criteria for dissolution for 12 units of gelatin capsules or gel-coated tablets if the failure can be unequivocally attributed to gelatin cross-linking These exceptions do not apply to physical change as exempli ed by phase separation of a semisolid dosage form, creams, or other occurrences at accelerated conditions, and if such a change occurs, testing at the intermediate condition should be performed..





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12. Select both keyframes in the Style property by clicking the property name or by dragging a selection marquee around both. 13. Right-click one keyframe, and choose Hold Interpolation.

It will execute easily enough and return the result shown in Figure 11.1. It looks like XML, so what s the problem Upon closer examination, you ll see that the XML returned by the query isn t XML at all! Notice that Internet Explorer didn t render it with the customary colored tags. When you look at the source, you ll see that all of the essential XML characters have been escaped and replaced with their URLencoded equivalents. What a shame! In the context of this example, it seems that you have uncovered a horrible failing of XSQL. But it isn t, really. XSQL s default behavior is to assume that XML isn t being returned. Thus, it s proper and required to escape the special XML characters. As you ll see, the workarounds are pretty easy. In this chapter, you ll learn about the PL/SQL-based workaround. You can also retrieve XML with the help of custom XSQL action handlers, as you ll see in 18, Custom Action Handlers.

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Number of HS-SCCH codes allocated in the cell (see Section 3.4.3). Number of HS-PDSCHs supported by the UE. Power needed to satisfy each user target bit rate (e.g., estimated using (5.13)). Total allocated HSDPA power (see Figure 5.25).

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