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The prototypes of these problems are quite famous: If the channel is a noiseless quantum channel, and the task is the conveyance of classical data, then this is the superdense coding [520] problem, in which one use of the channel, and the consumption of one entangled EPR (Einstein, Podolsky, Rosen) pair, results in two bits sent The generalization of this to a noisy quantum channel gives a capacity that has been called CE [578, 579]; useful entropic expressions for CE have been derived, and it is known to be additive..



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Figure 3.9. Two-electron, two-orbital interaction: (a) both electrons in lower orbital, dative bond formation and electron transfer from B to A; (b) one electron in each orbital, large stabilization and covalent bond formation.





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Because of the importance of water as the universal biological solvent, biochemical samples are usually handled and studied as aqueous solutions or suspensions. Some techniques described in this book involve interactions between biological samples present in solution/suspension and some sort of immobile stationary phase. These experiments may be critically affected by the ow characteristics of the solution/suspension (e.g. column chromatography, 2; capillary electrophoresis, 5). Moreover, common experimental manipulations in biochemistry such as centrifugation, dialysis and ltration are strongly in uenced by ow interactions arising from hydrodynamic properties of the sample. These properties arise from physical interactions between molecules or particles and aqueous solvent. They are even more important in large-scale industrial situations encountered in biotechnology such as downstream processing of protein products ( 2; Section 2.5.2). In order to understand such experimental situations more fully, it is helpful to consider the physical basis of hydrodynamic properties. This chapter will summarize the principal hydrodynamic properties of biomacromolecules and will describe their in uence on ow-based experimental systems such as centrifugation, ltration, dialysis and ow cytometry. For simplicity, biomacromolecules (such as DNA and proteins), macromolecular complexes (such as ribosomes and viruses) and large biological entities (such as organelles and cells) are referred to as particles throughout this chapter.

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Frequency (MHz)

(4 kO in parallel with 12 kO)

The resulting equivalent <select> element becomes this:

made and when 8 Can the business rank order its customers by profitability, including the accurate and beneficial assignment of all costs t o those customers (see point r) Is there a formal process for gathering customers wants, 9 needs and their willingness to pay for functionality I 0 I s there a similar process for gathering competitive product and cost information Is there an attempt t o ascertain competitors future product/cost intentions Could the business initiate a target cost planning process, I1 replacing a more traditional cost plus methodology Has the percentage of costs that may be directly assigned I2 t o products increased Can the business calculate the change What proportion of cost management time and cost is I3 devoted to the design stages, as against prototype and production stages I 4 W h o is involved in the product planning process Is it a cross-functional team Have the business s underlying cost systems been 15 modified to provide a foundation for product cost planning

A possible thermodynamic interpretation of protein folding is to think of the folded conformation as occupying a lower free energy value than any of the unfolded conformations. It could be imagined that the protein might sample all possible conformations until the lowest energy conformation was randomly arrived at. This is known as Levinthal s paradox and it may be explained by examining folding of a 100-residue protein. If it was assumed that each residue could adopt ten possible conformations (which is much less than the number of likely conformations available to most residues) then; Total number of conformations = 10100 (6.5)

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