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Therapeutics Committee (Schachtner et al, 2002) This committee produces an evidence-based, consensus-driven guide to drug therapy known as the formulary system Through therapeutic interchange, a pharmacist dispenses a formulary drug, when a nonformulary drug has been ordered for a patient Unlike generic substitution, which involves the dispensing of a different brand of the same drug, therapeutic interchange results in the dispensing of an entirely different drug that is within the same class of drugs as the ordered drug Only when an order for a more expensive medication can be rmly justi ed will it be dispensed in place of the formulary drug The pressures for ef ciency in the use of pharmaceuticals can be expected to increase with the advent of pharmacogenomics These will be expensive drugs Those who pay for them will want to be certain that there is value in them.



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Less cohesive communities might fall apart because of such problems as interface difficulties, internal disagreements, miscommunication, absence of strong leadership, and the occasional breakdown in group connectivity. They require much more technical reliability and better custom interface design to keep them together.





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A lower a motivates more small customers to participate, while the extra cost is recovered by the higher p Remember that small customers do not mind paying more than marginal cost prices, but cannot afford a paying a high xed fee Other models assume a xed cost per customer and a variable cost that depends on usage This is the case for setting up an access service, such as for telephony or the Internet Depending on the particular market, a and p may be above or below the respective values of the xed customer cost and the marginal cost of usage 553 Other Nonlinear Tariffs General nonlinear tariffs can be functions of the form rx/, where x is the amount consumed by the customer Starting with r.

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Pharmacists will be asked to oversee the use of expensive drugs produced through the application of pharmacogenomics, and pharmacy regulators will ensure that this oversight is done responsibly Simply because a drug is expensive does not mean that its use should be denied But it can be expected that any order for an expensive drug will be closely scrutinized, and the order will be lled only if the characteristics of the patient justify use of the drug Just as they have done with generic substitution and therapeutic interchange of traditional drug products, pharmacists will interface between the prescribers of pharmacogenomics-based drugs and the third-party payers It will be the pharmacist s responsibility to determine that expensive drug therapies based on pharmacogenomics are used only when sound science warrants their use Decisions about the availability of expensive drug therapies are best made when data about therapeutic outcomes can be readily accessed.

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0/ D 0 they retain the nice property of Ramsey prices, that customers who have low valuations for the service can participate by paying an arbitrarily small amount The optimal rx/ may have both convex and concave parts A general property is that the customer purchasing the largest quantity q sees a marginal charge r 0 q/ equal to marginal cost In many practical situations, rx/ is a concave function In this case, the price per unit drops with the quantity purchased, a property known as quantity discounts In practice, smooth tariffs are approximated by block tariffs These are tariffs in which the range of consumption is split into intervals, with constant per unit prices A more interesting class of nonlinear tariffs are optional two-part tariffs.

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