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Although the ADOS consists of four modules, an individual is given only one module, which is selected based on his or her developmental level and overall expressive language ability George was given Module 1, which is designed for young children who have no speech and a maximum of simple phrases It consists of 10 activities with 29 accompanying ratings The activities focus on the playful use of toys and other materials that are salient to children with developmental ages of less than 3 During the administration of the ADOS, George did not use any recognizable words, but when he vocalized, all of his vocalizations were socially directed He did use the examiner s hand as a tool to make requests He also, however, made requests by reaching to objects with coordinated eye gaze.



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He used eye gaze very well to modulate social interactions, demonstrated a range of facial expressions, exhibited shared enjoyment in interactions, and demonstrated play skills that were appropriate as compared to his developmental level Mr Fine also completed the Behavior and Sensory Interests questionnaire, which assesses more details related to behaviors that are not uncommon in children with autism and a variety of other genetic syndromes George has repetitive hand and nger movements, taps objects in a repetitive manner, throws objects, and is quite obsessed with plastic He has some unusual sensory interests as well (looking at things out of the corner of his eyes, licking objects as a way of exploration, and smelling objects) Some aggressive behaviors (eg, occasional hitting and biting) were noted for George as well..

The assembly is shown in Figure 7-41.





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Figure 5.7 The design of an optional tariff. The demand functions of the various customer types are linear, parallel, and distributed between a smallest x min . p/ and a largest x max . p/. An optional tariff E 1 C p1 x is added to the Ramsey prices p R . We start with E 1 D AB D E and p1 D MC. This tariff appeals to customers with demand function of x M or more, increases social welfare since they consume more and balances costs. By further decreasing E 1 , and slightly increasing p1 to MC C , we induce customer type M to use the optional tariff and produce a welfare gain of H M . This is substantially greater than the welfare loss of H2 that arises because the larger customer consumer slightly less.

The very complex structure of morphine proposed by Robinson and Schopf was not fully accepted for some years after it was proposed. Today s array of instrumental technology, including X-ray diffraction, nuclear magnetic resonance, and infrared absorption, makes it generally possible to assign detailed chemical structures to unknown samples with a high degree of certainty. The only proof of structure considered acceptable before the availability of those tools comprised total synthesis. This still acceptable criterion required that the compound in question be synthesized from starting materials whose structure was rmly established by a sequence of unambiguous transforms. In pursuit of that goal, Grewe in Germany succeeded in 1948 in synthesizing a compound that included a simpli ed form of the morphine skeleton.16,17 This still, however, lacked the ve-membered ring present in the natural product or for that matter any substitution on the terminal ring. The observation that this molecule nonetheless exhibited considerable analgesic activity in animal models spurred work in a number of laboratories aimed at investigating this basic nucleus, dubbed a morphinan (Fig. 5). Scientist at Hoffmann La-Roche published work on this series as early as 1949.18 As general rule, organic reactions that produce molecules that can exist as mirror images will result in an exact 50 : 50 mixture of those products. The product from the Grewe synthesis thus consists of such a mixture of stereoisomers. Separation of the mixture, called

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