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The symptoms of hypocalcemic tetany may be confused with paresthesias, muscle cramps, or tetany due to respiratory alkalosis, in which the serum calcium is normal In fact, hyperventilation tends to accentuate hypocalcemic symptoms Chronic hypocalcemia can cause heart failure and be confused with myocardial infarction and ischemic cardiomyopathy At times hypoparathyroidism is misdiagnosed as idiopathic epilepsy, choreoathetosis, or brain tumor (on the basis of brain calcifications, convulsions, choked disks) or, more rarely, as asthma (on the basis of stridor and dyspnea) Hypocalcemia is frequently seen in patients with hypoalbuminemia; serum levels of ionized calcium are normal Hypocalcemia may also be due to malabsorption of calcium, magnesium, or vitamin D; patients do not always have diarrhea Hypocalcemia may also be caused by certain drugs: loop diuretics, plicamycin, phenytoin, alendronate, and foscarnet In addition, hypocalcemia may be seen in cases of rapid intravascular volume expansion or due to chelation from transfusions of large volumes of citrated blood Hypocalcemia is also frequently seen following parathyroidectomy for hyperparathyroidism It is also observed in patients with acute pancreatitis Hypocalcemia may develop in some patients with certain osteoblastic metastatic carcinomas (especially breast, prostate) instead of the expected hypercalcemia Hypocalcemia with hyperphosphatemia (simulating hypoparathyroidism) is seen in azotemia but may also be caused by large doses of intravenous, oral, or rectal phosphate preparations and by chemotherapy of responsive lymphomas or leukemias Hypocalcemia with hypercalciuria may be due to a familial syndrome involving a mutation in the calcium-sensing receptor; such patients have levels of serum PTH that are in the normal range, distinguishing it from hypoparathyroidism It is transmitted as an autosomal dominant disorder Such patients are hypercalciuric; treatment with calcium and vitamin D may cause nephrocalcinosis



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A Emergency Treatment for Acute Attack (Hypoparathyroid Tetany)

This usually occurs after surgery and requires immediate treatment 1 Airway Be sure an adequate airway is present

% Plot the torque-speed curves figure(1); plot(t_ind,n,'b-','LineWidth',20); xlabel('\bf\tau_{ind} (N-m)'); ylabel('\bf\itn_{m} \rm\bf(r/min)'); title ('\bfDifferentially-Compounded DC Motor Torque-Speed Characteristic'); axis([0 250 800 1350]); grid on;

The goal should be to maintain the serum calcium in a slightly low but asymptomatic range (8 86 mg/dL) This will minimize the hypercalciuria that would otherwise occur and provides a margin of safety against overdosage and hypercalcemia, which may produce permanent damage to renal function

Available Preparations Ergocalciferol ergosterol, (vitamin D2, Calciferol) Cholecalciferol (vitamin D3) Calcitriol (Rocaltrol) Capsules of 50,000 IU; 8000 IU/mL oral solution Daily Dose 2000 200,000 units Duration of Action 1 2 weeks

Before diving into the newer standards, let s get a few facts about Ethernet out of the way:





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Capsules of 50,000 IU not available commercially in United States; may be compounded Capsules of 025 and 05 mcg; 1 mcg/mL oral solution; 1 mcg/mL for injection

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Calcium supplementation (1 2 g/d) is given, along with a vitamin D preparation Patients with chronic hypoparathyroidism must be treated with some type of vitamin D (Table 26 9) Vitamin D2 (ergocalciferol) is derived from plants and is commercially available The usual dose ranges from 25,000 to 150,000 units/d Vitamin D3 (cholecalciferol), the form of vitamin D that is naturally produced in unprotected human skin with UV sunlight exposure, is not generally commercially available in the United States in large doses but may be compounded Vitamin D3 is at least three times more bioavailable than vitamin D2, so that appropriate dosing adjustments must be made when changing from one type of vitamin D to another Both forms of vitamin D are slow-acting preparation, and if toxicity develops, hypercalcemia treatable with hydration and prednisone may persist for weeks after it is discontinued Ergocalciferol and cholecalciferol usually produce a more stable serum calcium level than do the shorter-acting preparations Despite its high cost, calcitriol is being used with increasing frequency for the treatment of chronic hypoparathyroidism; the maintenance dosage of calcitriol ranges from 025 mcg/d to 20 mcg/d Monitoring of serum calcium at regular intervals (at least every 3 months) is mandatory PTH acts upon the kidney to increase tubular reabsorption of calcium Therefore, patients with hypoparathyroidism are prone to hypercalciuria and calcium nephrolithiasis during treatment Target serum calcium levels should be 8 86 mg/dL, keeping it mildly low to avoid hypercalciuria It is prudent to monitor urine calcium with spot urine determinations and keep the level below 30 mg/dL if possible Hypercalciuria may respond to oral hydrochlorothiazide, usually given with a potassium supplement Caution: Phenothiazine drugs should be administered with caution, since they may precipitate extrapyramidal symptoms in hypocalcemic patients Furosemide should be avoided, since it may worsen hypocalcemia

Renal stones, polyuria, hypertension, constipation, fatigue, mental changes Bone pain; rarely, cystic lesions and pathologic fractures Serum and urine calcium elevated; urine phosphate high with low to normal serum phosphate; alkaline phosphatase normal to elevated Elevated PTH

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The resulting plot is shown below:

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