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The hallmark of hairy cell leukemia is pancytopenia Anemia is nearly universal, and 75% of patients have thrombocytopenia and neutropenia Nearly all patients have striking monocytopenia, which is encountered in almost no other condition The hairy cells are usually present in small numbers on the peripheral blood smear and have a characteristic appearance with numerous cytoplasmic projections The bone marrow is usually inaspirable (dry tap), and the diagnosis is made by characteristic morphology on bone marrow biopsy The hairy cells have a characteristic histochemical staining pattern, with tartrate-resistant acid phosphatase (TRAP) On immunophenotyping, the cells coexpress the antigens CD11c and CD22 Pathologic examination of the spleen shows marked infiltration of the red pulp with hairy cells This is in contrast to the usual predilection of lymphomas to involve the white pulp of the spleen



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Hairy cell leukemia should be distinguished from other lymphoproliferative diseases such as Waldenstr m s macroglobulinemia and non-Hodgkin s lymphomas It also may be confused with other causes of pancytopenia, including hypersplenism due to any cause, aplastic anemia, and paroxysmal nocturnal hemoglobinuria

The treatment of choice is cladribine (2-chlorodeoxyadenosine; CdA), 014 mg/kg daily for 7 days This is a relatively nontoxic drug that produces benefit in 95% of cases and complete remission in more than 80% Responses are longlasting, with few patients relapsing in the first few years Treatment with pentostatin produces similar results, but that drug is more cumbersome to administer

Pancytopenia Splenomegaly, often massive Hairy cells present on blood smear and especially in bone marrow biopsy





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For the power system of Problem 13-6, calculate the subtransient fault current for a single-line-to-ground fault at Bus 4 if the neutrals of the three generators are all solidly grounded How much difference did the inclusion of the impedances to ground in the generator neutrals make to the total fault current Why would a power company wish to ground the neutrals of their generators through an impedance SOLUTION If the neutrals of the generators are solidly grounded, then the zero-sequence impedance of each generator will be much smaller However, this will have no effect on the current in a single-line-toground fault at Bus 4, because the connections of the Y- transformers effectively decouple the generators from Bus 4 in the zero-sequence network However, if the power system were configured differently so that the generators were connected to Bus 4 in the zero sequence network, the presence of the impedance in the ground line would reduce the current flowing in a single-line-to-ground or double-line-to-ground fault Under normal conditions, the current flowing in the ground of a generator is very small, because the loads on the generator are nearly balanced Therefore, an impedance in the ground line has little or no effect on steady-state operations, while reducing fault currents for single-line-to-ground or double-line-to-ground faults Since single-line-toground faults are the most common kind, it makes sense for a power company to include an impedance in the grounds of its generators

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Dedicated connection Using a non-dial-up connection to another private network or the Internet Remote terminal computer Using a terminal emulation program to connect to another

The development of new therapies has changed the prognosis of this disease Formerly, median survival was 6 years,

and only one-third of patients survived longer than 10 years It now appears that more than 95% of patients with hairy cell leukemia will live longer than 10 years

Chadha P et al Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience Blood 2005 Jul 1;106(1):241 6 [PMID: 15761021] Jehn U et al An update: 12-year follow-up of patients with hairy cell leukemia following treatment with 2-chlorodeoxyadenosine Leukemia 2004 Sep;18(9):1476 81 [PMID: 15229616]

Precursor B B cell lymphoblastic lymphoma Mature B Diffuse large B cell lymphoma Mediastinal large B cell lymphoma Follicular lymphoma Small lymphocytic lymphoma Lymphoplasmacytic lymphoma Mantle cell lymphoma Burkitt s lymphoma Marginal zone lymphoma MALT type Nodal Splenic Mucosal tissue associated Precursor T T cell lymphoblastic lymphoma Mature T (and NK cell) Anaplastic T cell lymphoma Peripheral T cell lymphoma

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print pdf document with javascript | Adobe Acrobat - AcrobatUsers.com
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Code to disable Print and Save As - JavaScript / Ajax / DHTML - Bytes
Code to disable Print and Save As. JavaScript / Ajax / DHTML Forums on Bytes. ... By using this site, you agree to our updated Privacy Policy and our Terms of Use . ... function noway(go) { if; (document.all) { if (event. button == 2) .... Do you want the PDF file to display in the browser without a dialog box or do ...












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