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Free PDF editor is one free and handy PDF editing and creating software help you create and make standard PDF documents in minutes not need Acrobat PDF ... Obesity has long been linked with various diseases and with premature death. Associations are well recognized with type 2 diabetes, hypertension, dyslipidaemia and vascular disease commonly grouped together as the metabolic syndrome and with osteoarthritis, sleep apnoea and the polycystic ovarian syndrome (PCOS). Obesity has also been implicated as a risk factor for many other diseases, including several malignancies and chronic renal failure (see Table 9.1). Wolf and Colditz (1998) and James et al. (2004) have estimated the proportion of total risk of developing several major diseases that can be attributed to obesity. There are some discrepancies between the two reports, probably due to differences in the study populations and sampling periods (Wolf and Colditz used only American data from the 1988 and 1994 National Health Interview Survey). Overall, however, obesity appears to contribute about 60% of the total risk for type 2 diabetes, up to 40% of that for hypertension and endometrial carcinoma, 20 30% of the risk for coronary heart disease, stroke, osteoarthritis and gall-bladder disease, and about 10% for carcinoma of the breast and colon (Figure 9.1). The relationship between risk and BMI varies considerably among these diseases, with the risk for type 2 diabetes rising particularly sharply as BMI increases above the normal range (Figure 9.2, and Figure 9.9 on page 226). This chapter reviews the key epidemiological evidence linking obesity to its main comorbidities and premature death, and touches on some of the possible aetiological mechanisms. We shall also discuss the predictive value of the various measures of obesity, and how risk is modulated by factors such as gender, ethnic origin, physical tness and smoking. Detailed accounts of the pathophysiology, clinical features and management of the major comorbidities can be found elsewhere in this book, namely type 2 diabetes (YN-1 nitro pdf editor software full version with keygen free download PDF Reader - Free PDF Editor Software Downloads - FileHippo
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