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Do not administer corticosteroids unless absolutely indicated or more conservative measures have failed Keep dosage and duration of administration to the minimum required for adequate treatment Screen for tuberculosis with a purified protein derivative (PPD) test or chest radiograph before commencing long-term corticosteroid therapy Screen for diabetes mellitus before treatment and at each physician visit Teach the patient about the symptoms of hyperglycemia and to test urine weekly for glucose Screen for hypertension before treatment and at each clinician visit Screen for glaucoma and cataracts before treatment, 3 months into treatment, and then at least yearly Prepare the patient and family for possible adverse effects on mood, memory, and cognitive function Inform them about other possible side effects, particularly weight gain, osteoporosis, and aseptic necrosis of bone Institute a vigorous physical exercise and isometric regimen tailored to each patient s disabilities Administer calcium (1 g elemental calcium) and vitamin D3, 400 800 IU orally daily Check spot morning urines, and alter dosage to keep urine calcium concentration below 30 mg/dL If the patient is receiving thiazide diuretics, check for hypercalcemia, and administer only 500 mg elemental calcium daily Consider a bisphosphonate such as alendronate (70 mg orally weekly) or periodic intravenous infusions of pamidronate or zoledronic acid Avoid prolonged bed rest that will accelerate muscle weakness and bone mineral loss Ambulate early after fractures Treat hypogonadism Avoid elective surgery, if possible Vitamin A in a daily dose of 20,000 units orally for 1 week may improve wound healing, but it is not prescribed in pregnancy Avoid activities that could cause falls or other trauma Watch for fungal or yeast infections of skin, nails, mouth, vagina, and rectum, and treat appropriately Ulcer prophylaxis: If administering corticosteroids with nonsteroidals,prescribe prophylaxis with a proton pump inhibitor (not required for corticosteroids alone) Avoid large doses of antacids containing aluminum hydroxide (many popular brands); aluminum hydroxide binds phosphate and may cause a hypophosphatemic osteomalacia that can compound corticosteroid osteoporosis Treat infections aggressively Consider unusual pathogens Weigh daily Use dietary measures to avoid obesity and optimize nutrition Measure height frequently This serves to document the degree of axial spine demineralization and compression Treat edema as indicated Monitor plasma potassium for hypokalemia Treat as indicated Obtain bone densitometry before treatment and then periodically Treat osteoporosis Counsel to avoid smoking and excessive ethanol consumption With dosage reduction, watch for signs of adrenal insufficiency or corticosteroid withdrawal syndrome.



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PDFKit
A JavaScript PDF generation library for Node and the browser. ... You can also read the guide as a self-generated PDF with example output displayed inline.

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Edit *existing* PDF in a browser - Stack Overflow
Quick answer - no and it is quite unlikely you will find a cross-browser solution. It is very unlikely that you will find a PDF -perfect solution.

nobarbital) accelerate the metabolism of corticosteroids other than hydrocortisone, making them significantly less potent Megestrol, a synthetic progestin, has slight corticosteroid activity that becomes significant when administered in high doses for appetite stimulation





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22 Jun 2018 ... By the end of the twentieth century, it is estimated that the Adobe Acrobat Reader (Adobe's software for reading and editing PDF files) had been ...

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In Acrobat, you can select Tools> JavaScript to edit document level scripts. For scripts that are associated with form fields, links, bookmarks, you need to edit the  ...

Prolonged treatment with systemic corticosteroids causes a variety of adverse effects that can be life-threatening Patients should be thoroughly informed of the major possible side effects of treatment such as insomnia, personality change, weight gain, muscle weakness, polyuria, kidney stones, diabetes mellitus, sex hormone suppression, occasional amenorrhea in women, candidiasis and opportunistic infections, osteoporosis with fractures, or aseptic necrosis of bones (particularly of the hips), which may become manifest many months after even brief treatment (see section on Cushing s syndrome) Patients who receive intermittent high-dose corticosteroids (eg, prednisone 15 mg daily and cumulative dose > 1 g) are at increased risk for osteoporotic fractures Avascular necrosis of bone develops in about 15% of patients who receive corticosteroids at high doses (eg, prednisone 15 mg daily) for more than 1 month with cumulative prednisone doses of 10 g

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PDFKit
A JavaScript PDF generation library for Node and the browser. ... You can also read the guide as a self-generated PDF with example output displayed inline.

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Bisphosphonates (eg, alendronate, 70 mg orally weekly) prevents the development of osteoporosis among patients receiving prolonged courses of corticosteroids For patients who are unable to tolerate oral bisphosphonates (due to esophagitis, hiatal hernia, or gastritis), periodic intravenous infusions of pamidronate, 60 90 mg, or zoledronic acid, 2 4 mg, should also be effective It is wise to follow an organized treatment plan such as the one outlined in Table 26 19

L1 impedance: X = j10 G1 ratings: 100 MVA 132 kV R = 005 pu XS = 08 pu T1 ratings: 100 MVA 138/120 kV R = 002 pu X = 008 pu

Ce P et al Avascular necrosis of the bones: an overlooked complication of pulse steroid treatment of multiple sclerosis Eur J Neurol 2006 Aug; 13(8):857 61 [PMID: 16879296] De Vries F et al Fracture risk with intermittent high-dose oral glucocorticoid therapy Arthritis Rheum 2007 Jan;56(1): 208 14 [PMID: 17195223] Rhen T et al Antiinflammatory action of glucocorticoids new mechanisms for old drugs N Engl J Med 2005 Oct 20;353 (16):1711 23 [PMID: 16236742]

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Treatment is less than adequate because available drugs are quite toxic, require long courses, and are mostly administered parenterally The drugs of choice have been pentavalent antimonials, but these drugs are quite toxic, and failures are increasing due to drug resistance Important newer therapies are amphotericin B and miltefosine

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Question: Is JavaScript required for embedding PDFs in your HTML page? ... By default, PDFObject inserts a fallback link to the PDF when the browser does not ...

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