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Any damage to the skin (irritation, allergy, infection, excoriation, burns, or dermatologic therapy such as chemical peels and freezing with liquid nitrogen) may result in hyperpigmentation or hypopigmentation Several disorders of clinical importance are described below 1 Hyperpigmentation The most common type of secondary hyperpigmentation occurs after another dermatologic condition, such as acne, and is most commonly seen in dark-skinned persons It is called postinflammatory hyperpigmentation Pigmentation may be produced by certain drugs, eg, chloroquine, chlorpromazine, minocycline, and amiodarone Fixed drug eruptions to phenolphthalein in laxatives, to trimethoprim-sulfamethoxazole, to NSAIDs, and to tetracyclines, for example, are further causes 2 Hypopigmentation Leukoderma is a disorder that may complicate atopic dermatitis, lichen planus, psoriasis, DLE, and lichen simplex chronicus Practitioners must exercise special care in using liquid nitrogen on any patient with olive or darker complexions, since doing so may result in hypopigmentation or depigmentation, at times permanent Intralesional or intra-articular injections of



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Although the color of skin may be altered by many diseases and agents, the vast majority of patients have either an increase or decrease in pigment secondary to some inflammatory disease such as acne or atopic dermatitis Other pigmentary disorders include those resulting from exposure to exogenous pigments such as carotenemia, argyria, deposition of other metals (such as gold when given long-term for rheumatoid arthritis), and tattooing Other endogenous pigmentary disorders are

One must distinguish true lack of pigment from pseudoachromia, such as occurs in tinea versicolor and seborrheic dermatitis The evaluation of pigmentary disorders in whites is helped by Wood s light, which accentuates epidermal pigmentation and highlights hypopigmentation





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Edit * existing * PDF in a browser - Stack Overflow
Quick answer - no and it is quite unlikely you will find a cross-browser solution. It is very unlikely that you will find a PDF -perfect solution.

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28 Aug 2018 ... The PDF apps you've likely used the most— Adobe Reader, Apple ... Sejda is the rare free PDF editor that can edit text or add form fields to a PDF . .... build mini- apps inside your PDF documents with JavaScript , and build ...

daily is the first-line therapy A superpotent corticosteroid may also be used, but local skin atrophy from prolonged use may ensue With 20 25% involvement, narrowband UVB or oral PUVA is best Severe phototoxic response (sunburn) may occur with oral PUVA The face and upper chest respond best, and the fingertips and the genital areas do not respond as well to treatment Years of treatment may be required Newer techniques of using epidermal autografts and cultured epidermis combined with PUVA therapy give hope for surgical correction of vitiligo

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Grimes PE New insights and new therapies in vitiligo JAMA 2005 Feb 9;293(6):730 5 [PMID: 15701915] Mehrabi D et al A randomized, placebo-controlled, doubleblind trial comparing narrowband UV-B Plus 01% tacrolimus ointment with narrowband UV-B plus placebo in the treatment of generalized vitiligo Arch Dermatol 2006 Jul; 142(7):927 9 [PMID: 16847214]

Actinic keratoses and skin cancers are more likely to develop in persons with vitiligo There may be severe emotional trauma in extensive vitiligo and other types of hypopigmentation and hyperpigmentation, particularly when they occur in naturally dark-skinned persons

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29 Aug 2013 ... (for example in a subdirectory called / Viewer .js ) put some ODF ... ViewerJS must be the easiest way to use presentations, spreadsheets, PDF's  ...

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Cicatricial baldness may occur following chemical or physical trauma, lichen planopilaris, bacterial or fungal infections, severe herpes zoster, chronic DLE, scleroderma, and excessive ionizing radiation The specific cause is often suggested by the history, the distribution of hair loss, and the appearance of the skin, as in lupus erythematosus Biopsy is useful in the diagnosis of scarring alopecia, but specimens must be taken from the active border and not from the scarred central zone Scarring alopecias are irreversible and permanent It is important to diagnose and treat the scarring process as early in its course as possible

Therapeutic bleaching preparations generally contain hydroquinone Hydroquinone has occasionally caused unexpected hypopigmentation, hyperpigmentation, or even secondary ochronosis and pigmented milia, particularly with prolonged use The role of exposure to ultraviolet light cannot be overstressed as a factor promoting or contributing to most disorders of hyperpigmentation, and such exposure should be minimized Melasma, ephelides, and postinflammatory hyperpigmentation may be treated with varying success with 3 4% hydroquinone cream, gel, or solution and a sunscreen containing UVA photoprotectants (Avobenzone, zinc oxide, titanium dioxide) Tretinoin cream, 0025 005%, may be added Superficial melasma responds well, but if there is predominantly dermal deposition of pigment (does not enhance with Wood s light), the prognosis is poor Response to therapy takes months and requires avoidance of sunlight Hyperpigmentation often recurs after treatment if the skin is exposed to ultraviolet light Solar lentigines respond to liquid nitrogen application Tretinoin, 01% cream and tazarotene 01% used over 10 months, will fade solar lentigines (liver spots), hyperpigmented facial macules in Asians, and postinflammatory hyperpigmentation in blacks New laser systems for the removal of epidermal and dermal pigments are available, and referral should be considered for patients whose responses to medical treatment are inadequate

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How to Add JavaScript Functionality to PDF Forms without Coding ...
You can get pretty fancy, even using the built-in JavaScript tools in a PDF editor , to handle number strings, email a completed form, and insert the current date or ...

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Hopding/pdf-lib: Create and modify PDF documents in any ... - GitHub
Support modification ( editing ) of existing documents. Work in all ... There are other good open source JavaScript PDF libraries available. However, most of them ...












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