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PDFKit
A JavaScript PDF generation library for Node and the browser. ... You can also read the guide as a self-generated PDF with example output displayed inline.

There are four clinical types 1 Asymptomatic neurosyphilis This form is characterized by spinal fluid abnormalities (positive spinal fluid serology, increased cell count, occasionally increased protein) without symptoms or signs of neurologic involvement 2 Meningovascular syphilis This form is characterized by meningeal involvement or changes in the vascular structures of the brain (or both), producing symptoms of chronic meningitis (headache, irritability); cranial nerve palsies (basilar meningitis); unequal reflexes; irregular pupils with poor light and accommodation reflexes; and when large vessels are involved, cerebrovascular accidents The cerebrospinal fluid shows increased cells (100 1000/mcL), elevated protein, and usually a positive serologic test for syphilis The symptoms of acute meningitis are rare in late syphilis 3 Tabes dorsalis This form is a chronic progressive degeneration of the parenchyma of the posterior columns of the spinal cord and of the posterior sensory ganglia and nerve roots The symptoms and signs are impairment of proprioception and vibration sense, Argyll Robertson pupils (which react poorly to light but well to accommodation), and muscular hypotonia and hyporeflexia Impairment of proprioception results in a wide-based gait and inability to walk in the dark Paresthesias, analgesia, or sharp recurrent pains in the muscles of the leg ( shooting or lightning pains) may occur Crises are also common in tabes: gastric crises, consisting of sharp abdominal pains with nausea and vomiting (simulating an acute abdomen); laryngeal crises, with paroxysmal cough and dyspnea; urethral crises, with painful bladder spasms; and rectal and anal crises Crises may begin suddenly, last for hours to days, and cease abruptly Neurogenic bladder with overflow incontinence is also seen Painless trophic ulcers may develop over pressure points on the feet Joint damage may occur as a result of lack of sensory innervation (Charcot joint) The cerebrospinal fluid may have a normal or increased cell count (3 200/mcL), elevated protein, and variable results of serologic tests 4 General paresis This is generalized involvement of the cerebral cortex with insidious onset of symptoms There is usually a decrease in concentrating power, memory loss, dysarthria, tremor of the fingers and lips, irritability, and mild headaches Most striking is the change of personality; the patient becomes slovenly, irresponsible, confused, and psychotic The cerebrospinal fluid findings resemble those of tabes dorsalis Combinations of the various forms of neurosyphilis (especially tabes and paresis) are not uncommon.



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Treatment of tertiary syphilis (excluding neurosyphilis) is the same as late latent syphilis Reversal of positive serologic tests does not usually occur A second course of penicillin therapy may be given if necessary There is no known method for reliable eradication of the treponeme from humans in the late stages of syphilis Viable spirochetes are occasionally found in the eyes, in cerebrospinal fluid, and elsewhere in patients with

adequately treated syphilis, but claims for their capacity to cause progressive disease are speculative In the presence of definite cerebrospinal fluid or neurologic abnormalities, one should treat for neurosyphilis The pretreatment clinical and laboratory evaluation should include neurologic, ocular, cardiovascular, psychiatric, and cerebrospinal fluid examinations

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The regimen of 24 million units of benzathine penicillin intramuscularly weekly for 3 consecutive weeks results in low to undetectable cerebrospinal fluid levels of penicillin, and treatment failures have been described when this regimen has been used to treat neurosyphilis For these reasons, current recommendations for the therapy of neurosyphilis include higher doses of short-acting penicillin to achieve better penetration and higher levels of drug in the cerebrospinal fluid Recommended regimens include 18 24 million units per day of aqueous crystalline penicillin G given as 3 4 million units intravenously every 4 hours or as a continuous infusion for 10 14 days Alternatively, 24 million units of procaine penicillin can be given intramuscularly once daily along with 500 mg of probenecid orally four times daily, both for 10 14 days Because of concerns about slowly dividing organisms that may persist after only 10 14 days of therapy, many experts recommend subsequent administration of 24 million units of benzathine penicillin intramuscularly once weekly for 3 weeks as additional therapy Ceftriaxone, 2 g intramuscularly or intravenously once daily for 10 14 days, can be used as an alternative to penicillin Because other regimens for neurosyphilis have not been adequately studied, patients with a history of an IgE-mediated reaction to penicillin should be skin tested for allergy to penicillin and, if positive, desensitized All patients should have spinal fluid examinations at 6month intervals until the cell count is normal Response may be gauged by clinical improvement and reversal of cerebrospinal fluid changes In general, cerebrospinal fluid white blood cell count and cerebrospinal fluid VDRL normalize more quickly (usually in 12 months) than cerebrospinal fluid protein concentration, which can remain abnormal for extended periods, making it less useful as an indicator of success or failure of therapy A second course of penicillin therapy may be given if the cell count has not decreased at 6 months or is not normal at 2 years Not infrequently, there is progression of neurologic symptoms and signs despite high and prolonged doses of penicillin These treatment failures may be related to the unexplained persistence of viable T pallidum in central nervous system or ocular lesions in at least some cases.

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PDFedit is a free open source pdf editor and a library for manipulating PDF documents, released under terms of GNU GPL version 2. It includes PDF manipulating library based on xpdf, GUI, set of command line tools and a pdf editor .

Interpretation of serologic tests should be the same for HIVpositive and HIV-negative persons Because syphilis has variable clinical manifestations and an unpredictable course, evaluation of case reports of unusual clinical or laboratory manifestations of syphilis in HIV-infected patients is difficult Although unusual serologic responses have been reported in HIV-positive patients, including high titers of nontreponemal

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Load PDF template and edit it · Issue #777 · MrRio/ jsPDF · GitHub
19 Jun 2016 ... Thank you for your idea. So, I would like to add some text into existing pdf . Please tell me how to do it? I using JsPDF ver 1.2.60 Thanks for your ...

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How to Add JavaScript Functionality to PDF Forms without Coding ...
You can get pretty fancy, even using the built-in JavaScript tools in a PDF editor , to handle number strings, email a completed form, and insert the current date or ...












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