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red blood cell size The serum ferritin will become abnormally low A ferritin value less than 30 mcg/L is a highly reliable indicator of iron deficiency The serum total ironbinding capacity (TIBC) rises Bone marrow biopsy for evaluation of iron stores is now rarely performed because of intraobserver variation in its interpretation After iron stores have been depleted, red blood cell formation will continue with deficient supplies of iron Serum iron values decline to less than 30 mcg/dL and transferrin saturation to less than 15% In the early stages, the MCV remains normal Subsequently, the MCV falls and the blood smear shows hypochromic microcytic cells With further progression, anisocytosis (variations in red blood cell size) and poikilocytosis (variation in shape of red cells) develop Severe iron deficiency will produce a bizarre peripheral blood smear, with severely hypochromic cells, target cells, hypochromic pencil-shaped cells, and occasionally small numbers of nucleated red blood cells The platelet count is commonly increased



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The resulting bus admittance matrices are:

Other causes of microcytic anemia include anemia of chronic disease, thalassemia, and sideroblastic anemia Anemia of chronic disease is characterized by normal or increased iron stores in the bone marrow and a normal or elevated ferritin level; the serum iron is low, often drastically so, and the TIBC is either normal or low Thalassemia produces a greater degree of microcytosis for any given level of anemia than does iron deficiency Red blood cell morphology on the peripheral smear is abnormal earlier in the course of thalassemia

Iron deficiency develops in stages The first is depletion of iron stores At this point, there is anemia and no change in

Microcytic Iron deficiency Thalassemia Anemia of chronic disease Macrocytic Megaloblastic Vitamin B12 deficiency Folate deficiency Nonmegaloblastic Myelodysplasia, chemotherapy Liver disease Increased reticulocytosis Myxedema Normocytic Many causes





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The oldest, slowest, and most common original phone connection is the Public Switched Telephone Network (PSTN) PSTN is also known as Plain Old Telephone Service PSTN is just a regular phone line, the same line that used to run into everybody s home telephone jacks from the central office of your local exchange carrier (LEC the telephone company that provides local connections and usually the one who owns your local central office) Because PSTN was designed long before computers were common, it was designed to work with only one type of data: sound Here s how it works The telephone s microphone takes the sound of your voice and translates it into an electrical analog waveform The telephone then sends that signal through the PSTN line to the phone on the other end of the connection That phone translates the signal into sound on the other end using its speaker The important word here is analog The telephone microphone converts the sounds into electrical waveforms that cycle 2400 times a second An individual cycle is known as a baud The number of bauds per second is called the baud rate Pretty much all phone companies PSTN lines have a baud rate of 2400 PSTN uses a connector called RJ-11 It s the classic connector you see on all telephones (Figure 14-18)

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The diagnosis of iron deficiency anemia can be made either by the laboratory demonstration of an iron-deficient state or by evaluating the response to a therapeutic trial of iron replacement Since the anemia itself is rarely life-threatening, the most important part of treatment is identification of the cause especially a source of occult blood loss

Ferrous sulfate, 325 mg three times daily, which provides 180 mg of iron daily of which up to 10 mg is absorbed (though

0 0 j 46659 j 28802 j 28802 j86406 j 28802 j 28802 Ybus,1 = j 28802 j 72280 0 0 j 28802 j 45469 0 0 0 0 j 48802 j 28802 j 28802 j86406 j 28802 j 28802 = j 28802 j 72280 0 0 j 28802 j 45469 0 0 0 0 j 64401 j14401 j14401 j 43203 j14401 j14401 = j14401 j139401 0 0 j14401 j 64401 0 0 j 01005 j 01628 j 00649 j 03231 j 00942 j 01596 j 00636 j 03210

Eichbaum Q et al Is iron gluconate really safer than iron dextran Blood 2003 May 1;101(9):3756 7 [PMID: 12707229] Makrides M et al Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial Am J Clin Nutr 2003 Jul;78(1):145 53 [PMID: 12816784] Yates JM et al Iron deficiency anaemia in general practice: clinical outcomes over three years and factors influencing diagnostic investigations Postgrad Med J 2004 Jul;80(945): 405 10 [PMID: 15254305]

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