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IEEE Transactions on Information Theory, 44(4):167&1672, 1998 33 A Wald The fitting of straight lines if both varables are subject to error The Annuls ofMathematical Statistics, 11:284-300, 1940 34 S Zacks The Theory o Statistical Inference New York: Wiley, 1971 f 35 S Zacks Parametric Statistical Inference: Basic Theory and Modem Approaches Oxford: Pergamon Press, 1981 36 PW Zehna Invarianceof maximum likelihoodestimators TheAnnah ofMathematica1 Statistics, 37:744, 1966 37 F Zhang Matrix Theory: Basic Results and Techniques New York: Springer, 1999..

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2.2 PROBABILISTIC BOUND: EQUIVALENT BANDWIDTH Statistical multiplexing is the interleaving of packets from different sources where the instantaneous degree of multiplexing is determined by the statistical characteristics of the sources. Contrast this with slotted time division multiplexing TDM., for example, where packets from a source are served for a certain duration at fixed intervals and the degree of multiplexing is fixed by the number of sources that can be fitted into an interval. The probability density function pdf. of statistically multiplexed independent sources is the convolution of the individual pdf s, and the probability that the aggregate traffic will reach the sum of the peak rates is infinitesimally small 10y48 ., much smaller than the loss characteristics of physical links. The ATM network, for example, has a loss probability of 10y8 , in which case guaranteeing a 10y9 loss rate at the upper layer is sufficient w6x. Hence, networks that support statistical multiplexing can achieve a higher level of utilization without sacrificing much in QoS. Probabilistic guaranteed service, such as the controlled load service CLS., exploits this statistical observation and does not provide for the worst-case sum-of-peak-rates scenario. Instead, using the statistical characterizations of current and incoming traffic, it guarantees a bound on the probability of lost packets: Pr aggregate traffic y available bandwidth . ) buffer 4 F ,





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The Presentation layer takes care of translating data from lower layers so the data is understood at the Application layer. This saves the Application layer the headache of having to translate the data itself. The translation also occurs at the Presentation layer when data is being passed down the stack from the Application layer. Note that the Presentation layer is not always needed61 and that the Application layer may actually work with the Session layer and keep the Presentation layer out of the loop. Here are some examples of the data formats that are de ned at the Presentation layer: American Standard Code for Information Interchange (ASCII) Binary Extended Binary Coded Decimal Interchange Code (EBCDIC) Joint Photographic Experts Group (JPEG) Musical Instrument Digital Interface (MIDI)

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Table 5-4 Option Codes OPTION CODE 0 1 3 5 6 24 31 32 33 34 OPTION Binary Echo Suppress go ahead Status Timing mark Terminal type Window size Terminal speed Remote ow control Line mode EXPLANATION Assumes that transmission is binary Repeats information received Suppresses go ahead signaling Lists the Telnet status Sets the timing mark Sets the terminal type Sets the window size Sets the terminal speed Sets the remote ow control Sets to line mode

pharmacopeial compendia have determined procedures to investigate biological and physical chemical properties of plastics. In general, tests do not include the measurement of the polymeric material or the additives themselves but the biological reactivity (toxicity screening) of their extracts. Extracts are generally obtained by autoclaving the plastic container lled with water at 121 C for 30 min or at 100 C for 2 h. Only containers for parenteral and ophthalmic preparations have a more controlled regulation since their risk of toxicity is more signi cant, and therefore assays for plastic additives are foreseen in some pharmacopeial compendia [5]. Regulatory guidelines for plastics for pharmaceutical containers also set limits for impurities other than additives. These are inorganic species (metallic and nonmetallic) that can also be present in plastic containers, and their determination serves as a quality criterion for the plastic material. They may or may not be related

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