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with only uncorrelated disturbance noise. 7.5.3.3 Correlated Sensor Noise The same sort of state augmentation can be done for correlated sensor noise fjk g, zk Hk xk Ak vk Bk jk ; 7:90



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1 for 0 0.075 demonstrate the lack of identi ability in 0 and 1 . We have information on the sum and are trying to deconvolve information in the likelihood for the separate parameters of the component distributions. Example 8.2: Retinopathy Data with Incomplete Observations. Recall the diabetic retinopathy example of Section 7.3.1. The full data, given in Table 7.2, consist of 11 incomplete observations which we did not include in our previous analysis. In the data, nine people were observed in state 1 and then in state 3. We do not know when transitions to state 2 were made. Two people were observed in state 2 and then in state 4, but not in between. This example extends the retinopathy model to include these 11 observations. We use the same parametric model as in Section 7.3.1 and the same priors. The likelihood function is given by (8.2), where the incomplete data portion of the likelihood is given by L( |Dincomplete ) =





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The Pap smear is the most effective cancer screening test ever developed. That being said, the following discussion will cover speci c problem areas related to the Pap smear and the implications for clinical management. The take-home message for several of these problems related to the Pap smear is that HPV testing with the current FDAapproved methodology is very helpful in guiding patient management. The rst issue is the sensitivity of the Pap smear. Randomized clinical trials have shown that the sensitivity of a single Pap smear to detect HSIL/carcinoma is in the range of 50% to 60%.1 HPV testing used in conjunction with cytology improves the sensitivity to detect HSIL/carcinoma to approximately 95%.12 It is likely that in the near future, HPV testing will become part of the general screening process in some fashion. HPV testing is likely to be most bene cial in women over 30 years of age where the positive predictive value of the test is higher due to the overall lower prevalence of HPV infection in this age group. Approximately 4% to 5% of all Pap smear tests return with the diagnosis of ASC-US. ASCUS is not a distinct biologic entity and encompasses both neoplastic and non-neoplastic conditions. One should expect that approximately 50% of women with the diagnosis of ASC-US are infected with high-risk HPV and approximately 10% to 20% of women with ASC-US have CIN 2 or CIN 3. HPV testing effectively segregates the 50% of women with ASC-US with true cancer risk from those patients with essentially no risk. While studies are not as clear for guiding the

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The court settlement in Elizabeth S. v. Gilhool (1987) provides guidance to schools regarding their responsibilities to physically handicapped and other health-impaired students who do not qualify under IDEA. This class action suit was initiated when a district refused to train school personnel to monitor the blood sugar levels of a 6-year-old with juvenile diabetes. It also addressed school responsibilities to a 6-year-old with spina bifida who walked with the assistance of braces and crutches. The court stated that the required school accommodations and services for students with physical or health impairments might include, but are not limited to, development of a plan to address any medical emergencies, school health services including monitoring of blood sugar levels, and arrangements for a child to take injections or medications, assistance with toileting, adjustment of class schedules, home instruction, use of an elevator or other accommodations to make school facilities accessible, adaptive transportation, and adaptive physical education and/or occupational therapy.

billing, event records, TAP records (described in GSM Association speci cations), security aspects, operation and maintenance aspects, and tracing have to be covered as well, often in separate speci cations, cf. paragraph 20.8 on work item management. For major work items, in the initial phase of the work, a requirement speci cation (in the 01 series) and a dedicated report on project scheduling and open issues (in the 10.xx series) have been created; these speci cations are normally not maintained in the later phases of work. For the speci cations from Release 99 on, see paragraph 20.6.4.

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