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Introducing PDFNetJS: A Complete Browser-Side PDF Viewer and Editor ... a javascript program that parses and understands the PDF file, and uses the canvas ... Patients with small distal short arm deletions of the X chromosome (Xp-) that include the SHOX gene often have short stature and skeletal abnormalities but have a low risk of ovarian failure Transmission of Turner syndrome from mother to daughter can occur There may be an increased risk of trisomy 21 in the conceptuses of women with Turner syndrome Patients with deletions of the long arm of the X chromosome (distal to Xq24) often have amenorrhea without short stature or other features of Turner syndrome Abnormalities or deletions of other genes located on both the long and short arms of the X chromosome can produce gonadal dysgenesis with few other somatic features MEN 1 is a familial autosomal dominant multiglandular syndrome, with a prevalence of 2 10 per 100,000 people The presentation of MEN 1 is quite variable, even in the same kindred Parathyroid, enteropancreatic, and pituitary tumors can be present in one individual, though not necessarily at the same time Nonendocrine tumors also occur, such as subcutaneous lipomas, facial angiofibromas, and collagenomas In some affected individuals, tumors may start developing in childhood, whereas in others, tumors develop late in adult life About 90% of patients with MEN 1 gave germline mutations that are inherited as an autosomal dominant trait Patients with MEN 1 usually have detectable mutations in the 10 exons of the menin gene, located on the long arm of chromosome 11 (11q13) MEN 1 gene testing is available at a few centers and is able to detect the specific mutation in 60 95% of cases If no mutation is detected, genetic linkage analysis can be done if there are several affected members in the kindred Gene testing permits the rest of the kindred to be tested for the specific gene defect and allows informed genetic counseling With close endocrine surveillance of affected individuals, the initial biochemical manifestations (usually hypercalcemia) can often be detected as early as age 14 18 years in patients with a MEN 1 gene mutation, although clinical manifestations do not usually present until the third or fourth decade Hyperparathyroidism is the first clinical manifestation of MEN 1 in two-thirds of affected patients, but it may present at. javascript wysiwyg pdf editor: Edit *existing* PDF in a browser - Stack Overflow jquery pdf editor How to Add JavaScript Functionality to PDF Forms without Coding ...
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