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(a) Accepting and validating drug products that failed to meet established standards or speci cations and any other relevant quality control criteria (i.e., dissolution rates, content uniformity, purity, potency) and then falsely recording the untruthful data as if the drug products did not fail (b) Accepting and validating the stability characteristics of drug products and then falsely recording the untruthful data as if the drug products did not fail (c) Documenting the examination and review of labels, when in truth and fact no review occurred (which results in inaccurate labels distributed with drugs) (d) Falsely documenting any components of master production and central records (e) Falsely documenting any component of the batch production and control records (f) Falsely describing testing methods when no (or inadequate) testing methods were performed (g) Failing to accurately make a written record of all written and oral complaints regarding a drug product and/or certifying that investigations were performed when they were not, falsely certifying that the ndings were negative when they were not, and so on (h) Falsifying records which would indicate manufacturing changes which require approval by the FDA (i) False representations that contain statements of fact in correspondence sent to the FDA addressing violations in an inspector s form 483 The FDA typically initiates progressive enforcement, as described in Figure 7. Once the FDA and DOJ decide to bring enforcement action, the U.S. courts have held that the FDA s interpretation of its cGMPs is entitled to substantial deference. As long as the FDA s interpretation of its regulations are reasonable and sensibly conforms to the purpose and wording of the regulations, courts are required to follow the FDA s interpretations. 1.2.4.2 Civil Proceedings



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What types of projects does the foundation fund Are these similar to the nonprofit organization s projects What size grants are typically given If seeking building funds, learn if the foundation gives to capital projects. Locate similar information concerning endowment, programs, seed money, and so on. This is the one area where the guidelines are black and white. No matter how compelling a case statement may appear, a foundation will not provide money for bricks and mortar if it doesn t support capital projects. This is also the one area where deciding to make a request, disregarding information that a foundation clearly won t fund such a request, can make a development program appear na ve and unprofessional. Does the foundation support organizations with specific programs and services If guidelines state a foundation only gives to botanical gardens, it is unlikely that a prep school can craft a presentation that fits the criteria. Does the foundation only fund pre-selected organizations If so, the first essential step is to find a personal connection to a decision maker before sending materials to the foundation. Does the foundation state geographic limitations Most foundations specify a geographic limitation, and qualifying organizations must meet the requirement. A facility might not need to be located in the specified geographic area if, perhaps, it serves a great number of people living in that area.

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From 4.29. and 4.43., we get d ik, s fluid . F Fik s . , Combining 4.42. and 4.44., we get d ik, s y Fik s F , Lmax rs ,

The theorem implies that if the pixel samples are taken more than 1/2fN apart, it will not be possible to reconstruct the original image completely from these samples because some information in the original image is lost. The difference between the original image and the image reconstructed from these samples is caused by the aliasing error. The aliasing artifact creates new frequency components in the reconstructed image called Moir patterns. For example, in a radiograph when the physical star e phantom contains radial patterns with frequency higher than the X-ray machine can resolve the star phantom X-ray image creates Moir patterns near the center of the star e

1.2.4 1.2.4.1

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