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Similar limited validation is required in cases where it concerns a fully validated method which is applied to a new matrix, a well-established but noncollaboratively studied method, and a scienti cally published method with characteristics given More profound validation is needed for methods published as such in the literature, without any characteristic given, and for methods developed in-house [84] Which performance criteria have to be evaluated depends also on the purpose of the method Different ICH/USP guidelines are set up for (1) identi cation tests, (2) impurity tests, and (3) assay tests An identi cation test ensures the identity of an analyte in a sample by comparison to a known reference material An impurity test is intended to con rm the identity of (limit impurity test) or to accurately quantify (quantitative impurity test) an impurity, de ned as an entity which may normally not be present.



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Everything is as expected until one realizes that the actual symmetries of HOMO and HOMO-1 of DABCO are reversed! The explanation must be that there is a secondary interaction with the C C sigma bonds which cannot be neglected This is shown in Figure B37b Because of the threefold symmetry, the three C C bonding orbitals interact to give H three group orbitals, one of which has a1 symmetry and a degenerate pair of e H sym HH metry Likewise, the sCC orbitals combine to form an orbital of symmetry a2 and a degenerate pair of symmetry e HH These are given on the right-hand side of Figure H HH B37b, although only the a1 and a2 combinations are drawn out explicitly.





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InteracH H tion of the occupied a1 combination of nN with the occupied a1 combination of sCC H H e ectively raises the a1 nN combination, mixed out of phase with the a1 sCC combiHH nation At the same time, the occupied a2 nN combination is lowered by in-phase HH interaction of the a2 sCC combination, evidently enough to end up below the raised H a1 orbital This interaction with the s bonding orbitals is strong enough to ``undo'' the weaker primary nN nN interaction..

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An assay test nally implies the major component or active ingredient in a sample and quanti es the drug substance as such as a whole or the drug substance in a drug product For an assay test, where the major component or active ingredient is supposed to be present at high levels, other criteria should be investigated than for an impurity test The same is valid for quantitative tests versus identi cation and limit impurity tests (Table 4) [55, 56, 72, 85] The literature gives a wide range of practical guidelines for the evaluation of method performance characteristics [58] Besides the diversity of approaches, also the terminology and way of reporting results vary widely Differences may occur depending on the purpose and the application eld of the method, and validation studies may become more dif cult as the complexity of the analysis increases [86].

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Figure 5-14

In many applications, full knowledge of the channel is often not available. Rather, the statistical information of the channel may be estimated. For example] we can assume that the channel can be expressed as

In what follows, terms and formulas are taken from the accepted IUPAC nomenclature for the presentation of results of chemical analysis [66] For each validation parameter, de nitions, ways of expression, determination guidelines, and acceptance criteria are reported in Table 5..

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Figure 3.55 Real (a) and imaginary parts (b) of the measured and extracted Y21 of the intrinsic FET for Vgs = 0.6 V, Vds = 5 V

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Problem 7. Explain why adaptive antenna arrays could improve the performance of satellite communication systems. In which ways is the link efficiency of such systems expected to be affected Problem 8. Discuss the differences between a switched beam receiver (Butler matrix) and an adaptive receiver employed by an antenna array.

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not a member of PIC, was permitted to sign agreements. Consequently, a less formal and more exible PIC/S was developed to continue the work of PIC. The PIC/S, which became operational in November 1995, is an informal arrangement without legal status between regulatory authorities instead of countries. The PIC and the PIC Scheme, operating together as PIC/S, provide an active and constructive cooperation in the eld of GMP [47]. The current members of PIC/S are Australia, Austria, Belgium, Canada, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, Ireland,

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