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By-products By-products are perhaps the most dif cult impurities to summarize since each drug has its own by-products that may appear as impurities. They are synthesized along with active ingredients and are generally dif cult to separate, owing to their similarity to the drug of interest. Most are isomeric species, differing from each other by the presence of only a small group or just by the position of a hydrogen atom. Even more dif cult to separate and, therefore, purify are chiral isomers. Modern drugs that contain only one chiral isomer as the active ingredient are yet more dif cult. Pharmacopeias usually present in the monographs the byproducts that can exist as impurity of an active ingredient. 6.1.2.2 Additives Additives are all formulation constituents other than the active ingredient. Although additives could be classi ed into excipients and vehicles (excipients for solid preparations and vehicles for liquid ones), there are several other agents used in pharmaceutical formulations with speci c functions such as preservatives, sweeteners, coatings, colorants, antioxidants, surfactants, emulsifying agents, and avors. Since they comprise a vast amount of products, this section will deal with additives for compounding pharmaceutical products for internal use only [17, 18]. Table 8 lists additives and the possible impurities they might present. The limits for these impurities were taken from manufacturers speci cation bulletins. To compound Table 8, products of pharmacopeial grade (USP, BP, Ph. Eur., DAB) were selected from quali ed suppliers (Merck, Aldrich, Sigma, Fluka, EMS, Riedel deHa n). 6.1.2.3 Decomposition of Formulation Constituents

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No corporation is likely to say this in its consumer education literature: Don t use Windows Just say no Microsoft products have many, many more worms, viruses, and Trojans attacking them than other platforms even in areas where Microsoft is not the leading vendor Microsoft Internet Information Services and SQL Server have less market share than their competitors, but both are the preferred targets of malware writers Let me repeat this The problem is not just that Microsoft is used more than other software This is a common defense It s demonstrably false in markets where Microsoft isn t used more.

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If the argument is that other operating systems are simply too spread out in a sea of Windows users, I recommend you study the Witty worm, in which a small population of potential victims (just those users who used certain versions of the ISS BlackIce firewall) was almost completely saturated It s entirely possible to compromise a niche platform Quite frankly, it takes more technical skill to maintain a hack-free Windows box than most people have, and many of those who do have the skill don t want to bother More than once I ve heard my security coworkers joke about how much spyware they found on their Windows laptops.

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