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has been related to a reduction in fecundity For example, zebra sh exposed to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) showed a dose-related reduction in egg numbers (Wannemacher, 1992) Speci cally, TCDD impaired development of previtellogenic and vitellogenic oocytes Zebra sh have also been used in life cycle studies Those exposed to a mixture of dichloroaniline and lindane stopped spawning irreversibly, whilst sh exposed to the same xenobiotics after reaching maturity showed reduced fecundity (Ensenbach & Nagel, 1997) Fathead minnows (Pimephales promelas) exposed to lead showed a reduction in number of eggs oviposited despite no differences in GSI between treated and control sh (Weber, 1993) A negative correlation between concentration of the pesticide esfenvalerate and the fecundity of Australian crimson spotted rainbow sh (Melanotaenia uviatilis) has also been reported despite no effect on hepatic EROD, ECOD or EFCOD activities (Barry et al, 1995) Furthermore, radionuclides and chemical genotoxicants can affect fecundity.



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Mosquito sh (Gambusia af nis) exposed to radionuclides showed a negative correlation between fecundity and the level of double strand breaks in the DNA of sh from contaminated sites (Theodorakis et al, 1997) This relationship between xenobiotic exposure and reduced fecundity has been supported in some eld studies In redbreast sun sh (Lepomis auritus) elevated levels of detoxi cation enzymes were associated with decreased fecundity which it was suggested was due to the reduced capacity of the liver to manufacture yolk proteins (Adams et al, 1992a,b) The inducibility of spawning in English sole (Parophrys vetulus) from four areas in Puget Sound varying in chemical contamination showed that those sh from the site with the highest levels of hydrocarbons and PCBs showed highest reproductive impairment.





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In 1990 Fairburn and Beglin gave a review of the prevalence studies on bulimia nervosa. This landmark review yielded the generally accepted prevalence rate of 1% of young females with bulimia nervosa according to DSM criteria. Table 2.3 summarizes two-stage surveys of bulimia nervosa in young females that have been published since the review by Fairburn and Beglin. Despite the different classi cations used (DSM-III versus DSM-III-R) and different types of prevalence rates provided (lifetime prevalence, e.g. Bushnell et al., 1990, versus point prevalence, e.g. Rathner & Messner, 1993), the aggregated prevalence rate according to

This was linked to low initial plasma oestradiol and ALP, high measures of contaminant exposure and a prevalence of pollution-associated liver lesions (Casillas et al, 1991) In winter ounder (Pleuronectes americanus) sampled from sites on the north-east coast of the USA, decreased egg weight and increased atresia was found in sh with high tissue concentrations of PCB (Johnson et al, 1994) However, this negative relationship is not always clear, particularly in eld studies in which the sh are subjected to both natural and anthropogenic impacts which can affect fecundity.

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3 4. Ox + mH + + ne 2 Red The redox reactions of organic compounds are influenced by the acid-base properties of the solvents. In protic solvents like water, many organic compounds (Q 0) are reduced by a one-step two-electron process, Q 0 + 2H + + 2e 3 QH2, although 2

with Eurex This partnership has my full support, stated Brennan9 The European press couldn t resist taking a shot at the CBOT: In a week when the Chicago Board of Trade, the world s largest oorbased derivatives exchange, nally embraced the electronic wizardry behind Eurex, seven of the world s eight largest xed income houses announced plans to set up a new screen broking system for the cash bond markets, and immediately signaled an intention to open up talks with LIFFE The developments underscore the speed with which the xed income markets are changing The CBOT, steeped in bureaucracy and conservative to the point of indolence, will have a fully operational electronic capacity in a matter of months.

For example, in an examination of the effects of ve di-ortho PCB congeners on fathead minnows, it was found that no signi cant impact was observed on reproductive success in terms of total number of eggs, clutch size, number of clutches or percent hatchability despite a signi cant reduction in growth of females and a signi cant body burden of the congeners (Suedel et al, 1997) In the winter ounder study performed by Johnson et al (1994), despite increased atresia, contaminant exposure had no clear negative impact on GSI, plasma oestradiol concentration or fecundity An examination of the effects of bleached kraft mill ef uent on reproductive parameters of white sucker (Catostomus commersoni) found that exposed sh showed strong induction of EROD activity In females testosterone and 17beta-oestradiol levels were signi cantly reduced but GSI was not affected The effect on fecundity was more variable.

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