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First described in mammalian cancer cell lines, this mechanism is related to the expression of a membrane permeability glycoprotein (Pgp) that confers the ability to lower the intracellular concentration of many different structurally and functionally unrelated toxic compounds below their toxic level (Gottesman & Pastan, 1993) This phenomenon is a major problem in cancer chemotherapy and tumours found to express the P-glycoprotein have been shown to have a poor prognosis (Chan et al, 1990) Nevertheless, multiple resistance is not restricted to cancer cell lines A related phenomenon occurs in tissues of a wide range of natural species in order to prevent xenobiotic accumulation by transporting toxic xenobiotics or endogenous metabolites out of the cell (Thiebaut et al, 1987; Ouellette & Borst, 1991; Wu et al, 1991) Marine organisms possess one or several proteins related to this transport system.

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successively through states N 1, N 2, . . . , 2, 1, 0 until extinction. The transition probabilities are derived analogously to those of the pure birth process. The death parameters 1 , 2 , . . . , N take the place of the birth parameters. The transition probabilities, Pn (t) = P [X(t) = n|X(0) = N ], are PN (t) = exp( N t) Pn (t) = n+1 n+2 N [Ann exp( n t) + + AN n exp( N t)] for n = N 1, . . . , 1, 0, where AN n = Akn = Ann = 1 ( N 1 N ) ( n N ) 1 ( N k ) ( k+1 k )( k 1 k ) ( n k ) 1 . ( N n ) ( n+1 n ) for n < k < N (7.5)

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Eventually, the CBOT refused to pay for the latest software upgrades, a cost of about $15 million, acknowledging that the expected bene ts from improved software would not justify the costs Eurex took it as a breach of formal agreements and threatened to invoke dispute resolution procedures against the CBOT14 The dispute ended when again a new agreement was reached by shortening the termination date from 2008 to 2003, allowing the two exchanges.

Studies using radiolabelled, photolabelled and uorescent compounds have shown that cells expressing this protein share some similar pharmacological behaviour with MDRpositive cancer cells (Kurelec, 1992; Holland-Toomey & Epel, 1993; Cornwall et al, 1995) The proposed role for this MXR mechanism in these marine animals is to serve as a defence system against environmental xenobiotics (Kurelec, 1992; Kurelec et al, 1996) In accordance with this hypothesis, some environmental xenobiotics, mainly hydrophobic pesticides, have been reported to interact with the mussel MXR-protein (Cornwall et al, 1995; Galgani et al, 1996) and differential expression levels of the MXR-protein have been found in mussels living in polluted and unpolluted waters (Minier et al, 1993)..

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When top is running, you can update and sort the process list in different ways. To immediately update the process list, press Space or Enter. Press Shift+n to sort by PID. Press Shift+p to sort by CPU usage. Press Shift+m to sort by memory usage. Press Shift+t to sort by CPU time consumed. You can also change the column to sort by using the Shift+< (sort column to left) or Shift+> (sort column to right) characters. Or, press f and select the letter of the column you want to sort by when the list of columns appears. There are several ways to change the behavior of top as it s running. Press d and type a number representing seconds to change the delay between refreshes. Press u and enter a user name to only display processes for the selected user. To view only a select number of processes, type n and type the number you want to see. Press = at any point to return to the original top display. You can act on any of the running processes in different ways. To signal (kill) a running process, type k followed by the PID of the process you want to send the signal to. Then type 9 to end it or a different signal number to send that signal to the process. To give a process higher or lower run priority, type n and then add a negative number (to increase priority) or a positive number (to reduce priority).

Section I contained 25 multiple choice items examining the defendant s vocabulary and concepts. Section II contained 15 multiple choice items to assess the defendant s ability to assist in his/her own defence and to understand proceedings in court. Section III contained 10 open-ended questions examining the defendant s ability to relate factual events and understand the charges.

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