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Ramsey FL, Shafer DW The Statistical Sleuth: A Course in Methods of Data Analysis Belmont, CA: Duxbury Press; 1996 26 Kerr MK, Martin M, Churchill GA, Analysis of variance for gene expression microarray data J Comput Biol 2000;7:819 837 27 Pan WA Comparative review of statistical methods for discovering differentially expressed genes in replicated microarray experiments Bioinformatics 2002;18:546 554 28 Singer JD Using SAS PROC MIXED to t multilevel models, hierarchical models, and individual growth models J Educ Behav Stat 1998;24:323 355 29 Tusher VG, Tibshirani R, Chu G Signi cance analysis of microarrays applied to the ionizing radiation response Proc Natl Acad Sci USA 2001;98:5116 5121 30 Thomas JG, Olson JM, Tapscott SJ, Zhao LP An ef cient and robust statistical modeling approach to discover differentially expressed genes using genomic expression pro les Genome Res 2001;11:1227 1236 31 Efron B, Tibshirani R.



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1997, pp 1431/1432) Although this laboratory study might be a good example of a high stake study, it also raises serious ethical concerns To what extent is it ethically acceptable to threaten people so much, just for the sake of an experiment See Vrij (2002b) for a discussion concerning ethical issues in deception research Whatever researchers try, the best insight into deceptive behaviour in real-life situations will be obtained by examining people s behaviour in such situations This is exactly what some researchers recently did (Davis and Hadiks, 1995; Vrij and Mann, 2001b; Mann et al, 2002) For example, Vrij and Mann (2001b) examined videotapes of a murderer when he was questioned by the police regarding his crime The man initially denied having committed the crime, but confessed following the presentation of indisputable evidence.

Empirical Bayes methods and false discovery rates for microarrays Genet Epidemiol 2002;23:70 86..





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Davis and Hadiks (1995) analysed Saddam Hussein s behaviour while he was interviewed by CNN during the Gulf War Interestingly, the murderer in Vrij and Mann s study did not show a clear pattern of nervous behaviours, neither did Saddam Hussein while he lied during his CNN interview An explanation why nervous behaviours might still not be present in high-stakes lie situations is that liars probably will experience increased cognitive load and/or attempted behavioral control, which will negate their nervous behaviours In the most extensive study examining the behaviour of authentic high-stake liars to date, Mann et al (in submission) analysed, amongst others, the behaviour of 13 male suspects during their police interviews The strongest indicator for deceit in that study was eye blinking, with 11 out of the 13 male suspects (85%) showing less eye blinking while lying.

If perceptions of increased market risk become manifest in moves out of risky assets (namely, Eurodollar-denominated securities that are dominated by bank issues) and into safe assets (namely, US Treasury.

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research into BED or atypical cases of AN and BN can yield important information about core features of disordered eating Striegel-Moore et al (1999b) suggest that EDNOS cases might even be those with the highest prevalence rates Findings of Kinzl et al (1999) point into the same direction Striegel-Moore et al s (1999a) sample of eating disordered male veterans had a mean age of 517 years (SD = 142) and EDNOS subjects were the subgroup with the highest mean age Although the authors did not give information about age at onset of the disorder, this relatively high mean age draws attention to more atypical, but still at-risk cases of eating disorders For future research there exists also a clear need for multi-centre studies to compensate for the effects of small sample sizes on the one hand (Oyebode et al.

This is an interesting nding since research on eyeblinks has shown that these decrease as a result of cognitive load (Bagley and Manelis, 1979; Bauer et al, 1985; Wallbott and Scherer, 1991), but increase as a result of stress (Harrigan and O Connell, 1996; Tecce, 1992) In other words, our nding suggests that these suspects experienced more cognitive load than stress during their interviews However, since we did not directly test this hypothesis, this conclusion should be drawn with caution In summary, the authentic high-stakes studies conducted so far do not support the idea that liars show nervous behaviours Instead, liars tend to show behaviours which indicate cognitive load or attempted behavioural control However, we have to be careful with drawing this conclusion The studies examining behaviour during authentic high-stakes lies have only examined behaviours shown by criminals (and Saddam Hussein).

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