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In the early 1970s, before the introduction of the Apple I, the personal computing products available on the market had limited appeal They were generally sold by small electronics rms and individual hobbyists through clubs In many ways, Wozniak s Apple I still typi ed the early merchandise It consisted of an unpackaged circuit board wired by Wozniak so that a purchaser could hook it up to a power supply Within a few years, however, astonishing advances in integrated circuitry provided the critical raw materials needed And programmers began writing software to make the machines appealing to people In 1977, Wozniak and Jobs introduced the Apple II In stark contrast to the Apple I, fundamentally a kit computer with limited appeal though creatively priced at $666, the $1298 Apple II is considered by many to be the rst personal computer designed for the mass market.



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The prolonged survival of patients with impaired immunity is becoming more and more commonplace. The number of patients on cytotoxic drugs and steroids for the treatment of malignant disease, and to suppress immunity in connective tissue disorders and after organ transplantation, is increasing. The incidence and prevalence of AIDS are also increasing. These immunosuppressed or immunode cient patients are susceptible to infections (Fig. 15.5): by organisms which are capable of causing infection in normal individuals, but which cause abnormally frequent and severe infections in the immunocompromised; by organisms which are not pathogenic in normal circumstances, so-called opportunistic infections. The clinical features of these infections are often ill-de ned and not distinct from the patient s underlying disease. The different organisms do not create diagnostic clinical syndromes. Intensive investigation, in close collaboration with the microbiology laboratory, is usually required to establish the diagnosis and the correct treatment.





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Market appeal came from its attractive physical design, and the fact that it came fully assembled with a standard keyboard, integrated power supply, and color graphics capability From its start, Apple Computer had the necessary magic, in terms of both faith and hustle, to become a successful venture It was a classic American business story featuring two high school graduates with little money, no training in business or economics, and big dreams Wozniak designed and built the machines; Jobs provided the faith and the hustle It is interesting to note that in 1979 Jobs visited Xerox PARC and had a chance to see the future of computing PARC and Apple set up an agreement in which Apple provided Xerox 100,000 private shares of stock at the price of $10.

This, however, can be true only when all patents in the portfolio were issued on the same date and will expire on the same date in the future. In real life this rarely happens. To overcome this problem, we first note that

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As with many things in life, the devil is in the details It is necessary though not sufficient to know the types of covenants contained within a given debenture It is imperative to know how the covenants are represented and how they sit relative to the overall package of proposed covenants While it is probably rare that a particular covenant or set of covenants would inspire a rating agency to offer a credit rating a notch above what it would have otherwise been assigned, it certainly can be argued that the absence of key covenants can mean a far messier situation for a given issuer if things were to begin falling apart.

50 per share, in exchange for the alliance between the two organizations that allowed Apple engineers in on some of the PARC secrets related to GUI technology After the Apple engineers played with Xerox s GUI for a day, they went back to Apple and started to work on implementing the ideas they saw Software is always an issue for new computing systems At rst, many Apple programmers developed software primarily for games But by 1979, the technology began to mature, and applications such as database management, word processing, and spreadsheets all had been introduced With the emergence of these applications, large numbers of people realized that the small computers could help them manage information more productively As a result, the personal computing market measured revenues in the billions of dollars by 1981.

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