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There are other good open source JavaScript PDF libraries available. However, most of them can only create documents, they cannot modify existing ones (e.g. ... taken for polydipsia) and leukocytosis not due to infection are fairly common Other side effects include goiter (3%; often euthyroid), hypothyroidism (10%; concomitant administration of lithium and iodide or lithium and carbamazepine enhances the hypothyroid and goitrogenic effect of either drug), changes in the glucose tolerance test toward a diabetes-like curve, nephrogenic diabetes insipidus (usually resolving about 8 weeks after cessation of lithium therapy), nephrotic syndrome, edema, folate deficiency, and pseudotumor cerebri (ophthalmoscopy is indicated if there are complaints of headache or blurred vision) A metallic taste, hair loss, and Raynaud s phenomenon have been reported in a few cases Thyroid and kidney function should be checked at 3- to 4-month intervals Most of these side effects subside when lithium is discontinued; when residual side effects exist, they are usually not serious Most clinicians treat lithium-induced hypothyroidism (more common in women) with thyroid hormone while continuing lithium therapy Hypercalcemia and elevated parathyroid hormone levels occur in some patients Electrocardiographic abnormalities (principally T wave flattening or inversion) may occur during lithium administration but are not of major clinical significance Sinoatrial block may occur, particularly in the elderly Other drugs that prolong intraventricular conduction, such as TCAs, must be used cautiously in conjunction with lithium Lithium impairs ventilatory function in patients with airway obstruction Lithium alone does not have a significant effect on sexual function, but when combined with benzodiazepines (clonazepam in most symptomatic patients) it causes sexual dysfunction in about 50% of men Lithium may precipitate or exacerbate psoriasis in some patients Patients receiving long-term lithium therapy may have cogwheel rigidity and, occasionally, other extrapyramidal signs Lithium potentiates the parkinsonian effects of haloperidol Long-term lithium therapy has also been associated with a relative lowering of the level of memory and perceptual processing (affecting compliance in some cases) Some impairment of attention and emotional reactivity has also been noted Lithium-induced delirium with therapeutic lithium levels is an infrequent complication usually occurring in the elderly and may persist for several days after serum levels have become negligible Encephalopathy has occurred in patients receiving combined lithium and neuroleptic therapy and in those who have cerebrovascular disease, thus requiring careful evaluation of patients who develop neurotoxic signs at subtoxic blood levels Some reports have suggested that the long-term use of lithium may have adverse effects on renal function (with interstitial fibrosis or tubular atrophy) A rise in serum creatinine levels is an indication for in-depth evaluation of renal function and consideration of alternative treatments if the individual can tolerate a change Incontinence has been reported in women, apparently related to changes in bladder cholinergic-adrenergic balance Prospective studies suggest that the overall risk imposed by lithium in pregnancy may be overemphasized However, lithium exposure in early pregnancy does increase the frequency of congenital anomalies, especially Ebstein s and other major cardiovascular anomalies For women who take psychotropic medications who become pregnant, the decision to. generate pdf javascript: Save base64 string as PDF at client side with JavaScript - Stack ... generate pdf using jquery Generate PDF Invoices with Javascript – codeburst
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