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A HTML5 client-side solution for generating PDFs. Perfect for event tickets, reports, certificates, you name it! patients with severe sepsis and low risk of death (eg, APACHE II score < 25 or single organ failure), and since it is associated with serious bleeding complications, it should not be used in these patients Patients considered to have an infectious cause of severe sepsis (defined as three or more signs of systemic inflammation eg, fever or hypothermia, tachycardia, tachypnea plus sepsis-induced dysfunction of at least one organ system) of less than 24 hours duration are the best candidates Platelet counts less than 30,000/mcL, conditions associated with an increased risk of bleeding (eg, recent trauma, surgery, or bleeding episode; anticoagulation), or hypercoagulable states have not been investigated These criteria should be followed when selecting candidates for treatment with drotrecogin alfa (activated) The agent is administered intravenously by constant infusion at a dosage of 24 mcg/kg/h for 96 hours javascript pdf editor library Show HN: PDF Assembler – client-side PDF editing | Hacker News
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12 May 2017 ... I've written a JavaScript and would like to add it to the toolbar. How do I ... folder ( e.g. default is C:\Program Files\Tracker Software\ PDF Editor ), ... Abraham E et al; Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death N Engl J Med 2005 Sep 29;353(13):1332 41 [PMID: 16192478] Annane D et al Septic shock Lancet 2005 Jan 1 7;365(9453): 63 78 [PMID: 15639681] Friedrich JO et al Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis Crit Care 2006;10(3):145 [PMID: 16762040] Kumar A et al Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 2006 Jun; 34(6):1589 96 [PMID: 16625125] 192168042 34-67-22-01-98-11 Each per-unit impedance is converted to actual ohms referred to the low-voltage side by multiplying it by this base impedance The resulting equivalent circuit is shown below: Antibiotics should be given as soon as the diagnosis is suspected, since delays in therapy have been associated with increased mortality rates, particularly once hypotension develops In general, bactericidal antibiotics should be used and given intravenously to ensure therapeutic serum levels Penetration of antibiotics into the site of primary infection is critical for successful therapy ie, if the infection originates in the central nervous system, antibiotics that penetrate the bloodbrain barrier should be used eg, penicillin, ampicillin, chloramphenicol, and third-generation cephalosporins but not first-generation cephalosporins or aminoglycosides, which penetrate poorly Sepsis caused by gram-positive organisms cannot be differentiated on clinical grounds from that due to gram-negative bacteria Therefore, initial therapy should include antibiotics active against both types of organisms The number of antibiotics necessary remains controversial and depends on the cause Table 30 9 provides a guide for empiric therapy Although a combination of antibiotics is often recommended for synergism, combination therapy has not been shown to be superior to a single-drug regimen with any of several broad-spectrum antibiotics (eg, a thirdgeneration cephalosporin, piperacillin-tazobactam, carbapenem) If multiple drugs are used initially, the regimen should be modified and coverage narrowed based on the results of culture and sensitivity testing The role of corticosteroids in treatment of septic shock is still quite controversial Clinical data have suggested an association between mortality in patients with septic shock and poor adrenal reserve to cosyntropin (Cortrosyn) stimulation testing Administration of stress doses of hydrocortisone, for example 100 mg intravenously three times a day for 5 days followed by a 6-day tapering-dose regimen, to patients with relative adrenal insufficiency and pressor-dependent septic shock may reduce mortality However, the usefulness of cosyntropin stimulation testing and use of stress-dose hydrocortisone in patients with septic shock are not so well defined as to be standard of care pdf editor javascript Document Ready | WYSIWYG HTML Editor Examples | Froala
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