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the core of micelle can be a signi cant disruption of the polymer micelles. Another related issue that needs to be investigated is that the release of encapsulated guest molecules does not require a complete dissociation of BCP micelles; it may occur upon a disruption to various extents. For example, our recent studies found that swelling of BCP micelles in aqueous solution, as a result of an increased hydrophilicity of the core, is enough to start the release of loaded hydrophobic guest molecules. But most importantly, the photoisomerization of azobenzene and its derivatives is really an exceptional photoreaction (robust, clean, and reversible) whose marriage with BCPs provides a wonderful model system for developing light-controllable polymer nanocarriers. The design principles established through the studies of azobenzene-containing BCPs can be adapted to other bistable photoswitches displaying reversible photoisomerization and to other chromophores undergoing an appropriate photoreaction as well. Since the rst study on azobenzene BCPs that has revealed the key role of a photoswitchable or phototunable hydrophilic hydrophobic balance, various light-dissociable BCPs micelles using other chromophores have been reported (Lee et al., 2007; Jiang et al., 2007; Zhao, 2007b; Jiang et al., 2006, 2005).

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Using an INTERFACE DESCRIPTION in a separate file, a code generator generates code for CLIENT PROXY and INVOKER. The CLIENT PROXY used by the client adheres to the same contract as the INVOKER, which dispatches the invocation to the remote object. In this way the details required to ensure type safety are hidden from client and remote object developers. All they have to be concerned about is the INTERFACE DESCRIPTION and their own implementation based on that interface.

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I am grateful to all my students and collaborators who worked on and made contributions to our projects on azobenzene-containing block copolymer micelles, particularly, Dr. Guang Wang, Mrs. Xia Tong, and Dr. Bo Qi. I thank Mr. Yi Zhao for his assistance in the preparation of the manuscript. I also want to express my gratitude for the nancial support from the Natural Sciences and Engineering Research Council of Canada (NSERC), the Fonds pour la Formation de Cherch` eurs et l Aide a la Recherche of Quebec (FQRNT), University of Sherbrooke and St-Jean Photochemicals Inc. (St-Jean-sur-Richelieu, Quebec, Canada).

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E E E Usually an INTERFACE DESCRIPTION contains interface specifications that include their operations and signatures, as well as the definition of user-defined complex types. The INTERFACE DESCRIPTION itself can exist in various forms: Interface description language. The INTERFACE DESCRIPTION is separated from the program text, for example in a file provided by the remote object developer. An interface description language defines the syntax and semantics of the declarations. A code generator generates the remote object type specific parts of CLIENT PROXY and INVOKER. This allows interface violations to be detected automatically when compiling client and CLIENT PROXY. Note that this will only work if mechanisms exist that ensure that the isolated INTERFACE DESCRIPTION really conforms to the current version of the remote object interface.

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Arotcarena M, Heise B, Ishaya S, Laschewsky A. 2002. Switching the inside and the outside of aggregates of water soluble block copolymers with double thermoresponsivity. J Am Chem Soc 124:3787 3793. Bae Y, Fukushima S, Harada A, Kataoka K. 2003. Design of environment sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed Engl 42:4640 4643. Bellomo EG, Wyrsta MD, Pakstis L, Pochan DJ, Deming TJ. 2004. Stimuli responsive polypeptide vesicles by conformation speci c assembly. Nat Mater 3:244 248. Butun V, Armes SP, Billingham NC, Tuzar Z, Rankin A, Eastoe J, Heenan RK. 2001. The remarkable ip op self assembly of a diblock copolymer in aqueous solution. Macromolecules 34:1503 1511.

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