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1988). Considered as a package, the use of cytochemical tests as subcellular pathological probes can provide relatively speci c information. Autophagic (self-eating) processes play an important role in the degradation of intracellular proteins, particularly under conditions of stress or induced cell injury (Moore, 1990). There is abundant evidence of stress-induced autophagy in animal cells, including those of invertebrates, sh and mammals. In particular, the exposure of animals to pollutant chemicals (both metals and organic xenobiotics) is known to induce cell injury and ensuing pathological change, which frequently involves autophagy and lysosomal alterations (Moore, 1990; Lowe et al., 1995a,b). The latter include increased fragility of the lysosomal membrane, enlargement and in some cases lipidosis. Enhanced catabolism of cytosolic proteins has also been indicated in some experimental studies. However, there is still considerable debate concerning the relative importance of lysosomal as opposed to non-lysosomal pathways of intracellular protein catabolism. A great variety of xenobiotics are taken up by lysosomes (Rashid et al., 1991), and more recent work has indicated that lysosomotropic chemicals can enhance traf c of intracellular proteins to the degradative lysosomal compartment (Moore et al., 1996a).

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Figure 12-5 The scan-control mechanism in a CLSM. The sketch shows the delivery of the excitatory laser beam to the specimen by one of two galvanometer-driven mirrors that vibrate in mutually perpendicular axes within the confocal scan head. One mirror controls scanning along the x-axis, the other along the y-axis; both motions are coordinated to generate a pattern of a raster on the specimen. The speed and angular extent of deflection of the mirrors can be controlled to regulate the scanning rate and the extent of the scan.

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However, increased content of MT protein does appear to provide protection against DNA damage in mammalian systems (Abel & de Ruiter, 1989; Chubatsu & Meneghini, 1993; Cai & Cherian, 1996) There is not overwhelming evidence for an involvement of MT in antioxidant processes in sh, but there are some indications Olsson and co-workers have identi ed promoterregions in sh MT genes (AP1) that indicate that synthesis of MT in sh could be induced by exposure to free radicals (Kling & Olsson, 1995; Olsson & Kling, 1995) Furthermore, an induction of MT was seen in sh cell cultures following exposure to hydrogen peroxide (Kling et al, 1996) As yet, there is no knowledge of whether increased MT levels in sh tissues or cells confer protection against DNA damage 213.

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The javax.transaction.UserTransaction package in earlier releases of J2EE contained status codes. In the latest J2EE release, Sun moved the status codes out of the UserTransaction interface and placed the codes in a separate interface, javax.transaction.Status.

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The Values Exchange s Perception Rings ful l a similar preliminary function, though users are no longer asked to picture themselves . Instead they are asked to feel a gut reaction, and to select only those wedges that really resonate with them. Most of the wedge meanings have changed too, through trial and error as the software has developed. Using the Perception Rings rather than the older, paper-based Rings of Uncertainty Dr Wilson should be able to understand his human response more freely and immediately. Since his sense is that the baby should not be treated, he might select my emotion ; my role ; dignity and perhaps the law , perhaps like this:

5 Induction of stress proteins Stress proteins is a general term used to describe any protein for which there is an increased synthesis in response to a stressor In addition to heat-shock proteins (HSPs), this term also includes metallothionein, heme oxygenase and acute phase proteins Only HSPs will be considered here..

amount after a xed period. It is therefore not always too hard to guess correctly at the value. What can happen next is as shown in Figure 2.4.

of a two-year spot Treasury Not surprisingly, the short answer is It depends A number of statistical studies have been performed over the years to study the relationship between forward and spot yields and prices Generally speaking, the conclusions tend to be that forward values over short-term horizons have strong correlations with spot values of short-life assets (as with Treasury bills or shorter-dated Treasury bonds) Accordingly, it would be a reasonably safe statistical bet that the correlation would be strong between a two-year Treasury and an 18-month forward yield on an underlying six-month asset Why might this be of interest to a fixed-income investor Consider the following Let us assume that an investor believes that market volatility will increase dramatically, but that for some reason she is precluded from executing a volatility strategy with options.

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