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The disease families were initially identi ed because of the large number of affected individuals expressing an obvious phenotype, for example, severe disease with early age of onset Because of the rarity of the variant alleles causing a disease, only a single locus was responsible for the disease in each family In the initial families studied in the effort to clone the gene, all or most individuals with the variant allele exhibited the disease phenotype It was the availability of the large number of affected family members and clear evidence for genetic transmission that attracted researchers to these families The identi cation and characterization of these genes has provided great insight into disease processes and has resulted in identi cation of genes and proteins that are anticipated to be potential targets for intervention in disease processes.



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2) v NT tq C v = mf mi , 3) p P belongs to the covering trees AC(R, mi ) and AC(R, mf ), p then mf is reachable from mi in the net R Proof We build the ring sequence step by step First, condition 3 implies the existence of an increasing repetitive sequence 1 (for every place) from mi in R and an increasing repetitive sequence 4 (for every place) from mf in R Since R is consistent, a positive vector w with support T exists such that C w = 1 0 Since its support is T , there exists a big enough integer n such that w = n w Let us denote by an arbitrary sequence which ful lls = w 4 0 3 3 2 Finally, let us denote by 2 an arbitrary sequence ful lling = v.





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A recent study found that outcome was related to severity of autism (as measured by a rating scale) and cognitive ability at age 11 (Eaves & Ho, 2008) Eaves and Ho found that at age 24, the most common emotional or psychiatric problem was that of emotional dif culty (p 742); additional co-occurring disorders included bipolar disorder, depression, conduct disorder, Tourette syndrome, and anxiety disorder Of children with ASDs in a population-based cohort, 70% had at least one comorbid diagnosis; 41% had two or more diagnoses in addition to the ASD (Simonoff et al, 2008) The majority continued.

However, the variants in these genes have only limited impact on the total burden of a disease in the population because of the relative rarity of these alleles It is estimated that less than 5% of the disease burden for even such common diseases as breast cancer and Alzheimer disease are the result of variants in these disease genes..

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predictor, where changes to its parameters can greatly increase its effectiveness, leading to substantial improvement in performance The previously described schemes are designed for narrowband signals The ITU-T standardized a wideband codec known as G722 (ITU-T 1986) in 1986 It uses subband coding, where the input signal is split into two bands and separately encoded using ADPCM This codec can operate at bitrates of 48, 56, and 64 kbps and produces good quality for speech and general audio signals G722 operating at 64 kbps is often used as a reference for evaluating new codecs Parametric Codecs In parametric codecs, a multiple-parameter model is used to generate speech signals This type of codec makes no attempt to preserve the shape of the waveform, and quality of the synthetic speech is linked to the sophistication of the model.

Observe that 2 is a pseudo- ring sequence from mi to mf Let k 2 be an integer such that the marking of all places with k tokens makes the following sequences rable: the sequence 2 3 in R, and the sequence 3 in R We claim that mi 1 m1 2 m2 3 m3 3 m4 3 m5 4 mf is a ring sequence (we introduce intermediate markings to facilitate the proof) Let us compute the incidence of this sequence: 3 4 1 4 C k + +k +k =C v+k w + + 1 2 = C (v + k n w) = C v = mf mi So this sequence is a pseudo- ring sequence.

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