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Executives need to provide a clear vision and set the direction for their organization. Further, they need to put in place the culture, communication habits, and incentives that align with and move the organization toward their strategy. Executives also need to secure people and equipment with the right skills and capabilities, which is itself a capital-versus-spend balancing act. In the neverending end, the strategy must be tied to customer preferences and needs, but it must also satisfy the shareholders (i.e., owners) entitlement to wealth creation, not destruction. In the end, the organization needs top-down guidance with bottom-up execution. From the shop oor to the top oor and back again. PM bidirectionally converts plans into results. PM is not a theory, and it does not require a graduate degree to gure out how to get an organization to perform. However, without a set of tools and principles, it is dif cult to see what is going on, interpret what it means, and prescribe what to do. Things change quickly today and constant change is now the norm. A consequence is that proven methods of the past may not solve today s problems because the problems have changed. This makes understanding fundamental principles, such as matching the level of resources and their type with demand,

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[GIU 00] GIUA, A, PICCALUGA, A, SEATZU, G, Optimal token allocation in timed cyclic event graphs , International Workshop on Discrete Event Systems, Ghent, Belgium, p 209 218, 2000 [HIL 89] HILLION, H, PROTH, JM, Performance evaluation of a job-shop system using timed event-graphs , IEEE Transactions on Automatic Control, vol 34, no 1, 3 9, 1989 [JAC 98] JACQUET, P, Long Term Dependences and Heavy Tails in Traffic and Queues Generated by Memoryless On/Off Sources , Series, Rap Tech INRIA 3516, 1998 [KIN 62] KINGMANN, J F C, On Queue in Heavy Traffic , Journal of Royal Statistical Society, Series B, vol 24, 383 392, 1962 [KOR 02] KORBAA, O, CAMUS, H, GENTINA, J C, A New Cyclic Scheduling Algorithm for Flexible Manufacturing Systems , International Journal of Flexible Manufacturing Systems (IJFMS), vol 14, no.

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The overgrowth of this gland experienced by many men as they age often leads to adverse consequences. The minimal effect, benign prostatic hypertrophy (BPH), results in a variety of annoying effects caused largely by constriction of the urinary urethra by the enlarged gland. The far more serious consequence, prostatic cancer, is the major neoplasm found among aging men. Stimulation of the prostate by androgens and, more speci cally dihydrotestosterone, the active metabolite of testosterone, plays a role in both conditions. The search for an androgen antagonist that would block or at least diminish that stimulus dates back to the late 1960s. The nding that the estrogen antagonists identi ed at that time were useful in treating disease that involved estrogen-dependent tissues showed that this was a viable approach. As noted previously, discovery of the estrogen antagonists was aided by the availability of nonsteroidal estrogens. Research on androgen antagonists was made more dif cult by the fact that no nonsteroid androgen had yet been identi ed; the full steroid nucleus seemed to be required for androgenic activity. The rst androgen antagonist was in fact based on a compound that included a major portion of the steroid nucleus (Fig. 22). This compound, nasteride, reported in 1986 by a group from Merck,46 did however incorporate an important change from natural androgens. Replacement in this compound of the carbon atom at the 4-position by nitrogen transforms that ring into a cyclic amide. The binding af nity of that ring will differ from that of a normal all-carbon cyclic ketone. Finasteride is not an androgen antagonist by the strictest de nition of the term, which requires

Avoidants are painfully sensitive to humiliation and social disapproval, and they actively seek protection from the perceived inevitable threats of others in the environment. The DSM-IV describes avoidants as exhibiting a pattern of inadequacy and a fear that their shortcomings will expose them to judgment and ridicule. Several normal variants have been proposed, including Oldham and Morris s sensitive and vigilant styles and the hesitating pattern by Millon, Weiss, Millon, and Davis. The basic avoidant pattern is often mixed with other personality traits that are evidenced in several subtypes. The conflicted avoidant includes features of the negativistic personality where the basic withdrawal of the avoidant pattern is combined with the negativist s tendency toward interpersonal guerrilla warfare. The hypersensitive avoidant includes features of the paranoid personality but exhibits greater reality contact. Phobic avoidants combine features of the dependent and avoidant personalities, being especially prone to experiencing social phobias. The self-deserting avoidant combines social avoidance with the ruminative self-devaluation of the depressive personality. Most psychodynamic thinkers still consider the avoidant as part of the schizoid personality. However, three major psychodynamic theorists described personality patterns that are distinctly like the avoidant. Menninger (1930) described the isolated personality,

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