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Eight Table 8.1 # 1 a. 2. 2a . 3. r > 3. 4. Sequence of Operations for "Activate" OPERATION PERFORMED The CEE sends "activate" to wVendor, which ignores it other than to . . . . . .delegate it directly to wBase (that is, wVendor does not process this message at all) . wBase sends a "restore" message to "itself" (that is, to the bottom of the delegate chain-in this example, wVendor) . This allows any DC in the chain to handle its own data restore if it wishes and to ignore the framework . wBase sends "restore data" to the wPersistence component. The wPersistence component (a kind of local RDC in the UWD) retrieves the appropriate data from some form of persistent storage . Return of control (to wBase) occurs from inter-DC invocation 3 . The return carries with it data retrieved from the database by the wPersistence component. wBase then sends an "internalize" message to "itself ." The data retrieved by wBase from wPersistence is passed on this message as a string parameter containing tagged data . On receipt of this message, wVendor extracts the data it needs, and . . .



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Nature, 379 (6566), 632 635 LeGoff, DB, Leichner, P & Spigelman, MN (1988) Salivary response to olfactory food stimuli in anorexics and bulimics Appetite, 11 (1), 15 25 Legradi, G & Lechan, RM (1999) Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus Endocrinology, 140 (8), 3643 3652 Leibowitz, SF & Alexander, JT (1998) Hypothalamic serotonin in control of eating behavior, meal size, and body weight Biol Psychiat, 44 (9), 851 864 Leonard, T, Perpina, C, Bond, A & Tresaure, J (1998) Assessment of test meal induced autonomic arousal in anorexic, bulimic and control females Eur Eat Disord Rev, 6, 188 200 Li, BH, Xu, B, Rowland, NE & Kalra, SP (1994) c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption Brain.

For the examples in this book, the DAD is the same name as the schema the DAD accesses PORTAL30. However, although this practice is the default way of assigning names to a DAD, the DAD does not have to be the same as the schema name.

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Res, 665 (2), 277 284 Licinio, J, Wong, M-L & Gold, PW (1996) The hypothalamic-pituitary-adrenal axis in anorexia nervosa Psychiat Res, 62, 75 83 Lord, GM, Matarese, G, Howard, JK, Baker, RJ, Bloom, SR & Lechler, RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression Nature, 394 (6696), 897 901 Lowry, CA, Rodda, JE, Lightman, SL & Ingram, CD (2000) Corticotropin-releasing factor (CRF) increases in vitro ring rates of serotonergic neurons in the rat dorsal raphe nucleus: Evidence for activation of a topographically organised mesolimbocortical serotonergic system J Neurosci, 20 (7), 7728 7736 Mantzoros, C, Flier, JS, Lesem, MD, Brewerton, TD & Jimerson, DC.

Myasthenia gravis is the rare clinical disease that results from impaired neuromuscular transmission at the synapse between the termination of the axon of the lower motor neurone and the muscle, at the motor end plate. Figure 10.8 is a diagram of a motor end plate. Neuromuscular transmission depends on normal synthesis and release of acetylcholine into the gap substance of the synapse, and its uptake by healthy receptors on the muscle membrane. The main pathological abnormality in myasthenia gravis at the neuromuscular junction is the presence of auto-antibody attached to receptor sites on the post-synaptic membrane. This auto-antibody both degrades and blocks acetylcholine receptor sites, thus impairing neurotransmission across the synapse. Myasthenia gravis is an autoimmune disease in which the auto-antibody appears clearly involved in the pathogenesis of the muscle weakness. Myasthenia gravis is rather more common in women than men. In women, it tends to occur in young adult life, and in men it more commonly presents over the age of 50 years. Various subtypes of myasthenia gravis have been distinguished according to age and sex prevalence, HLAtype associations, incidence of auto-antibodies, and other characteristics. Muscle weakness, with abnormal fatiguability, and improvement after rest, characterize myasthenia gravis. Symptoms tend to be worse at the end of the day, and after repetitive use of muscles for a particular task, e.g. chewing and swallowing may be much more dif cult towards the end of a meal than they were at the start. The distribution of muscle involvement is not uniform, as shown in Fig. 10.9.

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