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When you want to offer your site visitors a range of choices, use checkboxes. Unlike radio buttons, checkbox options are nonexclusive. As you can see later in this chapter, with Spry checkboxes you can require both a minimum and maximum number of checkboxes, if desired. However, you need to follow a specific procedure mixing Spry and standard checkboxes to get the desired effect. Before the checkboxes are added, it s time to drop in the horizontal rule that s called for in the comp. 1. Shift-select both cells in the row below the radio buttons and in the Property inspector click Merge, the icon to the left of the Split icon. Click into the merged cell and choose Insert u HTML u Horizontal Rule. The horizontal rule expands to span both columns (Figure 10-10). Now you re ready to bring in the Spry checkbox.



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requirements; and they must be adaptable to commonly employed high-speed packaging equipment [89] Glass Containers Glass is commonly used in pharmaceutical packaging because it possesses superior protective qualities, it is economical, and containers are readily available in a variety of sizes and shapes It is essentially chemically inert, impermeable, strong, and rigid and has FDA clearance Glass does not deteriorate with age, and with a proper closure system, it provides an excellent barrier against practically every element except light Colored glass, especially amber, can give protection against light when it is required The major disadvantages of glass as a packaging material are its fragility and its weight The USP/NF [1] recognizes four major types of glass containers: Type I borosilicate glass containers are used for preparations that are intended for parenteral administration.





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Type II glass containers which are made of soda-lime glass that is suitably dealkanized are usually employed for packaging acidic and neutral parenteral preparations (type I glass may also be used for this purpose, but it is used for packaging alkaline parenteral preparations) Type III soda lime glass containers are not used for parenteral preparations except if stability data indicate otherwise The containers of the fourth category (type NP glass) are intended for packaging nonparenteral articles (ie, those intended for oral and topical use) Plastic Containers Plastics in packaging have proved useful for a number of reasons: The ease with which they can be formed, their high quality, and the freedom of design to which they lend themselves; plastic containers are extremely resistant to breakage and thus offer safety to consumers along with reduction of breakage losses at all levels of distribution and use [89].

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Plastic-coated glass bottles are used in aerosol containers to protect from ying glass in the event of glass shattering; further, plastic coating around the neck of the container serves to absorb some of the shock from the crimping operation and decreases the danger of breaking around the neck Plastic containers for pharmaceutical products are primarily made from the following polymers: (a) Polyethylene is a good barrier against moisture but a relatively poor one against oxygen and other gases; most solvents do not attack polyethylene, and it is unaffected by strong acids and alkalis; both high- and low-density polyethylene are used and they are long-chain polymers The density of polyethylene directly determines the four basic physical characteristics of the blow-molded container stiffness, moisture vapor transmission, stress cracking, and clarity or translucency and these characteristics determine the suitability of polyethylene used in containers for packaging drugs.

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The determinants of suitability of polyethylene have been identi ed by the USP/NF [1] as follows: oxygen and moisture permeability, modulus of elasticity, melt index, environmental stress crack resistance, and degree of crystallinity after molding) (b) Polypropylene polymers are long-chain polymers synthesized from propylene or propylene and other ole ns under controlled conditions of heat and pressure with the aid of catalysts Polypropylene does not stresscrack under any conditions Except for hot aromatic or halogenated solvents, which soften it, this polymer has.

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