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Familial benign hypocalciuric hypercalcemia can be easily mistaken for mild hyperparathyroidism It is a common autosomal dominant inherited disorder (prevalence: 1 in 16,000) caused by a loss-of-function mutation in the gene encoding the CaSR CaSRs are found on the surface of the parathyroid glands and allow the parathyroid glands to vary PTH secretion according to serum PTH levels Reduced function of the CaSR causes the parathyroid glands to falsely sense hypocalcemia and inappropriately release slightly excessive amounts of PTH At the same time, the renal tubule CaSRs are also affected, causing hypocalciuria Familial



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since the ratio E Ao , 2 / E Ao ,1 is the same as the ratio 2 / 1 Therefore, the final speed is

An effective live herpes zoster vaccine (Zostavax) is available to prevent both herpes zoster and postherpetic neuralgia It should be considered in persons aged 60 and older





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1 Immunocompetent host Since early treatment of zoster reduces postherpetic neuralgia, those with a risk of developing this complication should be treated, ie, those over age 50 and those with nontruncal eruption In addition, younger patients with acute moderate to severe pain or rash may benefit from effective antiviral therapy Treatment can be given with oral acyclovir, 800 mg five times daily; famciclovir, 500 mg three times daily; or valacyclovir, 1 g three times daily all for 7 days (see 32) For reasons of increased bioavailability and ease of dosing schedule, the preferred agents are those given three times daily Patients should maintain good hydration The dose of antiviral should be adjusted for renal function as recommended Nerve blocks may be important in the management of initial severe pain Ophthalmologic consultation is vital for involvement of the first branch of the trigeminal nerve Systemic corticosteroids are effective in reducing acute pain, improving quality of life, and returning patients to normal activities much more quickly They do not increase the risk of dissemination in immunocompetent hosts If not contraindicated, a tapering 3-week course of prednisone, starting at 60 mg/d, should be considered for its adjunctive benefit in immunocompetent patients Oral corticosteroids do not reduce the prevalence, severity, or duration of postherpetic neuralgia beyond that achieved by effective antiviral therapy 2 Immunocompromised host Given the safety and efficacy of currently available antivirals, most immunocompromised patients with herpes zoster are candidates for antiviral therapy The dosage schedule is as listed above, but treatment should be continued until the lesions have completely crusted

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The eruption persists 2 3 weeks and usually does not recur Motor involvement in 2 3% of patients may lead to temporary palsy

If you want to make a lot of money in the technology world, create a standard and then get everyone else to buy into it For that matter, you can even give the standard away and still make tons of cash if you have the inside line on making the hardware that supports the standard When it came time to come up with a new standard to replace 10BaseT, network hardware makers forwarded a large number of potential standards, all focused on the prize of leading the new Ethernet standard As a result, two UTP Ethernet standards appeared, 100BaseT4 and 100BaseTX 100BaseT4 used CAT 3 cable while 100BaseTX used CAT 5 By the late 1990s, 100BaseTX became the dominant 100-megabit Ethernet standard 100BaseT4 disappeared from the market and today it s forgotten As a result, we almost never say 100BaseTX today, simply choosing to use the term 100BaseT NOTE 100BaseT was at one time called Fast Ethernet The term still sticks to the 100-Mbps standards including 100BaseFX (discussed below) even though there are now much faster versions of Ethernet

Dworkin RH et al Recommendations for the management of herpes zoster Clin Infect Dis 2007 Jan 1;44(Suppl 1):S1 S26 [PMID: 17143845] Hornberger J et al Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults Ann Intern Med 2006 Sep 5;145(5):317 25 [PMID: 16954357] Oxman MN et al; Shingles Prevention Study Group A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults N Engl J Med 2005 Jun 2;352(22):2271 84 [PMID: 15930418]

Prodromal high fever Eruption progressing from papules to vesicles to pustules, then crusts All lesions in the same stage Face and distal extremities (including palms and soles) favored

Concern for the use of smallpox virus as a bioterrorist weapon has led to the reintroduction of vaccination in some segments of the population (first responders and the military)

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Moore ZS et al Smallpox Lancet 2006 Feb 4;367(9508):425 35 [PMID: 16458769]

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