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Alexander EK et al Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism N Engl J Med 2004 Jul 15;351(3):241 9 [PMID: 15254282] Appelhof BC et al Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial J Clin Endocrinol Metab 2005 May;90(5): 2666 74 [PMID: 15705921] Hennessey JV Levothyroxine dosage and the limitations of current bioequivalence standards Nat Clin Pract Endocrinol Metab 2006 Sep;2(9):474 5 [PMID: 16957756] Roos A et al The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial Arch Intern Med 2005 Aug 8 22;165(15): 1714 20 [PMID: 16087818] Wekking EM et al Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism Eur J Endocrinol 2005 Dec;153(6): 747 53 [PMID: 16322379]



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HYPERTHYROIDISM (THYROTOXICOSIS)

Sweating, weight loss or gain, anxiety, loose stools, heat intolerance, irritability, fatigue, weakness, menstrual irregularity Tachycardia; warm, moist skin; stare; tremor

% % % % % % M-file: prob3_10cm M-file to calculate and plot the secondary voltage of a three-phase Y-Y transformer bank as a function of load for power factors of 085 lagging, 10, and 085 leading These calculations are done using an equivalent circuit referred to the primary side

In Graves disease: goiter (often with bruit); ophthalmopathy Suppressed TSH in primary hyperthyroidism; increased T4, FT4, T3, FT3

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seen with interleukin-2 therapy and after neck surgery for hyperparathyroidism Patients taking lithium may rarely experience thyrotoxicosis due to silent thyroiditis Symptoms mimic a manic episode such that the diagnosis is often missed

The term thyrotoxicosis refers to the clinical manifestations associated with serum levels of T4 or T3 that are excessive for the individual (hyperthyroidism) Serum TSH levels are suppressed in primary hyperthyroidism However, laboratory tests can be affected by certain conditions and drugs that may lead to the erroneous diagnosis of hyperthyroidism in euthyroid individuals (Table 26 5) The causes of hyperthyroidism are many and diverse, as described below

Jodbasedow disease, or iodine-induced hyperthyroidism, may occur in patients with multinodular goiters after intake of large amounts of iodine in the diet or in the form of radiographic contrast materials or drugs, especially amiodarone

Thyrotoxicosis factitia is due to ingestion of excessive amounts of exogenous thyroid hormone Isolated epidemics of thyrotoxicosis have been caused by consumption of ground beef contaminated with bovine thyroid gland

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Graves disease (known as Basedow s disease in Europe) is the most common cause of thyrotoxicosis It is an autoimmune disorder affecting the thyroid gland, characterized by an increase in synthesis and release of thyroid hormones; the thyroid gland is typically enlarged Graves disease is much more common in women than in men (8:1), and its onset is usually between the ages of 20 and 40 years It may be accompanied by infiltrative ophthalmopathy (Graves exophthalmos) and, less commonly, by infiltrative dermopathy (pretibial myxedema) The thymus gland is typically hyperplastic and enlarged Graves disease may also be associated with other systemic autoimmune disorders such as pernicious anemia, myasthenia gravis, and diabetes mellitus It has a familial tendency, and histocompatibility studies have shown an association with group HLA-B8 and HLA-DR3 The pathogenesis of the hyperthyroidism of Graves disease involves the formation of autoantibodies that bind to the TSH receptor in thyroid cell membranes and stimulate the gland to hyperfunction Antibodies increased in most patients include TSH-R Ab[stim], antinuclear antibody (ANA), and antithyroperoxidase or antithyroglobulin antibodies Patients with Graves disease have an increased risk of developing Addison s disease, alopecia areata, celiac disease, diabetes mellitus type 1, myasthenia gravis, cardiomyopathy, and hypokalemic periodic paralysis

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