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Parathyroid hormone (PTH) increases osteoclastic activity in bone, increases the renal tubular reabsorption of calcium, and stimulates the synthesis of 1,25-dihydroxycholecalciferol by the kidney Meanwhile, PTH inhibits the absorption of phosphate and bicarbonate by the renal tubule All of these actions cause a net increase in serum calcium

Endemic goiter must be distinguished from all other forms of nodular goiter that may coexist in an endemic region (see above)

no of 1200 r/min Therefore,



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Iodine deficiency is prevented by adding potassium iodide to commercial salt, about 20 mg/kg salt Iodized salt has greatly reduced the incidence of endemic goiter Unfortunately, many iodine-deficient countries have inadequate programs for iodine supplementation The minimum dietary requirement for iodine is about 50 mcg daily, with optimal iodine intake being 150 300 mcg daily Iodine sufficiency is assessed by measurement of urinary iodide excretion, the target being more than 10 mcg/dL Initiating iodine supplementation in a geographic area causes an increased frequency of hyperthyroidism in the first year, followed by greatly reduced rates of toxic nodular goiter and Graves disease thereafter

Tetany, carpopedal spasms, tingling of lips and hands, muscle and abdominal cramps, psychological changes Positive Chvostek s sign and Trousseau s phenomenon Serum calcium low; serum phosphate high; alkaline phosphatase normal; urine calcium excretion reduced Serum magnesium may be low





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The addition of potassium iodide to table salt greatly reduces the prevalence of endemic goiter and cretinism but is less effective in shrinking established goiter Concurrent deficiencies in both vitamin A and iodine increase the risk of endemic goiter and concurrent repletion of both iodide and vitamin A reduces goiter in endemic goiter regions Dietary iodine supplementation increases the risk of autoimmune thyroid dysfunction, which may result in hypothyroidism or thyrotoxicosis Excessive iodine intake may increase the risk of goiter Levothyroxine supplementation can shrink goiters and reduce the risk of further goiter growth, but such treatment carries a risk of inducing hyperthyroidism in

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Hypoparathyroidism is most commonly seen following thyroidectomy, when it is usually transient but may be permanent It may also occur after surgical removal of a parathyroid adenoma for primary hyperparathyroidism due to suppression of the remaining normal parathyroids and accelerated remineralization of the skeleton (hungry bone syndrome) Calcium-sensing receptors (CaSR) on parathyroid gland cells sense the serum calcium concentration and alter PTH secretion by way of G-protein-coupled mechanisms Gain-of-

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