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Most patients present with symptoms related to expanded blood volume and increased blood viscosity Common complaints include headache, dizziness, tinnitus, blurred vision, and fatigue Generalized pruritus, especially following a warm shower or bath, may be a striking symptom and is related to histamine release from the increased number of basophils present Patients may also initially complain of epistaxis This is probably related to engorgement of mucosal blood vessels in combination with abnormal hemostasis due to qualitative abnormalities in platelet function Sixty percent of patients are men, and the median age at presentation is 60 years Polycythemia rarely occurs in persons under age 40 years Physical examination reveals plethora and engorged retinal veins The spleen is palpable in 75% of cases but is nearly always enlarged when imaged Thrombosis is the most common complication of polycythemia vera and the major cause of morbidity and death in this disorder Thrombosis appears to be related to increased blood viscosity and abnormal platelet function Uncontrolled polycythemia leads to a very high incidence of thrombotic complications of surgery, and elective sur-



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The first generation of DSL providers used a bridged connection; once the DSL line was running it was the same as if you snapped an Ethernet cable into your NIC You were on the network Those were good days for DSL You just plugged your DSL modem into your NIC and, assuming your IP settings were whatever the DSL folks told you to use, you were running The DSL providers didn t like that too much There was no control no way to monitor who was using the DSL modem As a result, the DSL folks started to use PPPoE, a protocol that was originally designed to encapsulate PPP frames into Ethernet frames The DSL people adopted it to make stronger controls over your DSL connection In particular, you could no longer simply connect; you now had to log on with an account and a password to make the DSL connection PPPoE is now predominant on DSL If you get a DSL line, your operating system has software to enable you to log onto your DSL network Most SOHO routers come with built-in PPPoE support, enabling you to enter your user name and password into the router itself (Figure 14-26)





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Spurious polycythemia, in which an elevated hematocrit is due to contracted plasma volume rather than increased red cell mass, may be related to diuretic use or may occur without obvious cause A secondary cause of polycythemia should be suspected if splenomegaly is absent and the high hematocrit is not accompanied by increases in other cell lines Arterial oxygen saturation should be measured to determine if hypoxia is the cause A smoking history should be taken; carboxyhemoglobin levels may be elevated in smokers A renal CT scan or sonogram may be considered to look for an erythropoietin-secreting cyst or tumor A positive family history should lead to investiga-

Spurious polycythemia Secondary polycythemia Hypoxia: cardiac disease, pulmonary disease, high altitude Carboxyhemoglobin: smoking Renal lesions Erythropoietin-secreting tumors (rare) Abnormal hemoglobins (rare) Polycythemia vera

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tion for congenital high-oxygen-affinity hemoglobin An absence of a mutation in JAK2 suggests a different diagnosis However, JAK2 mutations are also commonly found in the myeloproliferative disorders essential thrombocytosis and myelofibrosis Polycythemia vera should be differentiated from other myeloproliferative disorders (Table 13 14) Marked elevation of the white blood count (above 30,000/mcL) suggests chronic myelogenous leukemia This disorder is confirmed by the presence of the bcr/abl fusion gene Abnormal red blood cell morphology and nucleated red blood cells in the peripheral blood are seen in myelofibrosis This condition is diagnosed by bone marrow biopsy showing fibrosis of the marrow Essential thrombocytosis is suggested when the platelet count is strikingly elevated

Finazzi G et al; ECLAP Investigators Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study Blood 2005 Apr 1;105(7):2664 70 [PMID: 15585653] Landolfi R et al Efficacy and safety of low-dose aspirin in polycythemia vera N Engl J Med 2004 Jan 8;350(2):114 24 [PMID: 14711910] Marchioli R et al Vascular and neoplastic risk in a large cohort of patients with polycythemia vera J Clin Oncol 2005 Apr 1;23(10):2224 32 [PMID: 15710945] Tefferi A Polycythemia vera: a comprehensive review and clinical recommendations Mayo Clin Proc 2003 Feb;78(2):174 94 [PMID: 12583529]

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Print PDF directly from JavaScript - Stack Overflow
Then you call the . print () method on the element in Javascript when the PDF is loaded: function printDocument(documentId) { var doc ...

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