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Now that you have a feel for how long it s going to take, you need a strategy for studying The following has proven to be an excellent game plan for cramming the knowledge from the study materials into your head This strategy has two alternate paths The first path is designed for highly experienced technicians who have a strong knowledge of PCs and networking and want to concentrate on just what s on the exam Let s call this group the Fast Track group The second path, and the one I d strongly recommend, is geared toward people like me: the ones who want to know why things work, those who want to wrap their arms completely around a concept, as opposed to regurgitating answers just to pass the CompTIA Network+ exam Let s call this group the Brainiacs



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plasmodial antigens with a simple dipstick format These tests are not yet well standardized but are increasingly available around the world At best, they offer sensitivity and specificity near that of high-quality blood smear analysis and are simpler to perform Serologic tests indicate history of disease but are not useful for diagnosis of acute infection PCR is highly sensitive but not available for routine diagnosis In immune populations, highly sensitive tests, such as PCR, have limited value because subclinical infections, which are of uncertain significance and not routinely treated, are common Other diagnostic findings with uncomplicated malaria include thrombocytopenia, anemia, leukocytosis or leukopenia, liver function abnormalities, and hepatosplenomegaly Severe malaria can present with the laboratory abnormalities expected for the advanced end-organ dysfunction discussed above





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Most doses of antimalarial drugs are for uncomplicated malaria Although this disease is not usually rapidly lifethreatening, inappropriate therapy places individuals at increased risk for progression to severe malaria, and on a population level can impact greatly on malarial morbidity and mortality Decisions about how to treat malaria are affected by the potential for drug resistance, especially with P falciparum, the high cost of newer agents for developing world populations, and potential toxicity The drug sensitivity of individual strains can be studied in laboratory settings, but such testing is slow and not useful clinically Rather, therapeutic decisions are made based on the infecting species and geography P falciparum is now commonly resistant to older drugs, notably chloroquine and sulfadoxine-pyrimethamine, in most areas, with the principal exception of Central America west of the Panama Canal and Hispaniola Falciparum malaria from other areas should not be treated with these older drugs, and decisions regarding appropriate chemoprophylaxis should follow the same geographic considerations In the developing world, malaria is often treated with suboptimal regimens due to the high cost and limited supplies of newer agents In particular, chloroquine is still widely used in Africa, and its poor efficacy may be underappreciated due to its antipyretic properties, the ability of some immune individuals to recover from acute malaria without effective therapy, and the fact that recrudescences may not lead to symptoms until weeks after partially effective therapy Some countries have changed their first-line therapy for falciparum malaria from chloroquine to sulfadoxine-pyrimethamine, but

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Malaria is the most common cause of fever in much of the tropics and also the most common cause of fever in travelers after return from endemic areas Fevers are often treated presumptively in endemic areas, but ideally, treatment should follow definitive diagnosis, especially in nonimmune individuals Symptomatic malaria is caused only by the erythrocytic stage of infection Nearly all available antimalarial drugs act against this stage (Table 35 2) The exception is primaquine, which acts principally against hepatic stages

Drug Chloroquine Amodiaquine1 Quinine Quinidine Mefloquine Primaquine Sulfadoxine-pyrimethamine (Fansidar) Atovaquone-proguanil (Malarone) Chlorproguanil-dapsone (Lapdap)1 Doxycycline Halofantrine1 Lumefantrine1 Artemisinins1

(d) The per unit resistance and reactance of the transmission line are:

Class 4-Aminoquinoline 4-Aminoquinoline Quinoline methanol Quinoline methanol Quinoline methanol 8-Aminoquinoline Folate antagonist combination Quinone-folate antagonist combination Folate antagonist combination Tetracycline Phenanthrene methanol Amyl alcohol Sesquiterpene lactone endoperoxides

Use Treatment and chemoprophylaxis of infection with sensitive parasites Treatment of infection with some chloroquine-resistant Plasmodium falciparum strains Oral treatment of infections with chloroquine-resistant P falciparum Intravenous therapy of severe infections with P falciparum Chemoprophylaxis and treatment of infections with P falciparum Radical cure and terminal prophylaxis of infections with Plasmodium vivax and Plasmodium ovale Treatment of infections with some chloroquine-resistant P falciparum Treatment and chemoprophylaxis of P falciparum infection Treatment of multidrug-resistant P falciparum in Africa Treatment (with quinine) of infections with P falciparum; chemoprophylaxis Treatment of infections with some chloroquine-resistant P falciparum Treatment of P falciparum malaria in fixed combination with artemether (Coartem) Treatment of infection with multidrug-resistant P falciparum, generally in combination regimens

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Not available in the United States Reproduced, with permission, from Katzung BG Basic & Clinical Pharmacology 10th edition McGraw-Hill, 2007

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