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infection follows ingestion of raw, undercooked, or pickled freshwater fish containing metacercariae These parasites excyst in the duodenum and ascend into the biliary tract, where they mature and remain for many years, shedding eggs in the bile Most patients harbor few parasites and are asymptomatic An acute illness can occur 2 3 weeks after initial infection, with fever, abdominal pain, tender hepatomegaly, urticaria, and eosinophilia The acute syndrome is difficult to diagnose, since ova may not appear in the feces until 3 4 weeks after onset of symptoms In chronic heavy infections, findings include abdominal pain, anorexia, weight loss, and tender hepatomegaly More serious findings can include recurrent bacterial cholangitis and sepsis, cholecystitis, liver abscess, and pancreatitis An increased risk of cholangiocarcinoma has been documented Early diagnosis is presumptive, based on clinical findings and epidemiology Subsequent diagnosis is made by finding characteristic eggs in stool or duodenal or biliary contents Repeated concentration tests of stool may be necessary Imaging studies show characteristic biliary tract dilatations with filling defects due to flukes Serologic tests can be helpful but are limited by suboptimal specificity The drug of choice is praziquantel A dosage of 25 mg/kg orally three times daily for 2 days provides cure rates over 95% One day of treatment may be sufficient Re-treatment may be required, especially in some areas with known decreased praziquantel efficacy The second-line drug is albendazole (400 mg orally twice daily for 7 days), which appears to be somewhat less effective



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The large intestinal fluke, Fasciolopsis buski, is a common parasite of pigs and humans in eastern and southern Asia Eggs shed in stools hatch in fresh water, followed by infection of snails, and release of cercariae that encyst on aquatic plants Humans are infected by eating uncooked plants, including water chestnuts, bamboo shoots, and watercress Adult flukes mature in about 3 months and live in the small intestine attached to the mucosa, leading to local inflammation and ulceration Other intestinal flukes that cause similar syndromes include Heterophyes (North Africa and Turkey) and Metagonimus (East Asia) species; these species are transmitted by undercooked freshwater fish Infections with intestinal flukes are often asymptomatic, although in this case eosinophilia may be marked In symptomatic cases, after an incubation period of 1 2 months, manifestations include epigastric pain and diarrhea Other gastrointestinal symptoms, ileus, edema, and ascites may be seen uncommonly Diagnosis is based on identification of characteristic eggs or adult flukes in the stool In contrast to other fluke infections, illness more than 6 months after travel in an endemic area is unlikely The drug of choice is praziquantel, 25 mg/kg as a single dose Alternative therapies are triclabendazole and niclosamide (for most species)





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Jeon K et al Clinical features of recently diagnosed pulmonary paragonimiasis in Korea Chest 2005 Sep;128(3):1423 30 [PMID: 16162738] Keiser J et al Chemotherapy for major food-borne trematodes: a review Expert Opin Pharmacother 2004 Aug;5(8):1711 26 [PMID: 15264986] Keiser J et al Emerging foodborne trematodiasis Emerg Infect Dis 2005 Oct;11(10):1507 14 [PMID: 16318688] Saba R et al Human fascioliasis Clin Microbiol Infect 2004 May;10(5):385 7 [PMID: 15113313] Sezgin O et al Hepatobiliary fascioliasis: clinical and radiologic features and endoscopic management J Clin Gastroenterol 2004 Mar;38(3):285 91 [PMID: 15128078] Wang KX et al Clinical and epidemiological features of patients with clonorchiasis World J Gastroenterol 2004 Feb 1;10(3): 446 8 [PMID: 14760777]

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Eight species of Paragonimus lung flukes cause human disease The most important is Paragonimus westermani Paragonimus species are endemic in East Asia, Oceania, West Africa, and South America, where millions of persons are infected Eggs are released into fresh water, where parasites infect snails, and then cercariae infect crabs and crayfish Human infection follows consumption of raw, undercooked, or pickled freshwater shellfish Metacercariae then excyst, penetrate into the peritoneum, and pass into the lungs, where they mature into adult worms over about 2 months Most persons have moderate worm burdens and are asymptomatic In symptomatic cases, abdominal pain and diarrhea develop 2 days to 2 weeks after infection, followed by fever, cough, chest pain, urticaria, and eosinophilia Acute symptoms may last for several weeks Chronic infection can cause cough productive of brown sputum, hemoptysis, dyspnea, and chest pain, with progression to chronic bronchitis, bronchiectasis, bronchopneumonia, lung abscess, and pleural disease Ectopic infections can cause disease in other organs, most commonly the CNS, where disease can present with seizures, headaches, and focal neurologic findings due to parasite meningitis, and intracerebral lesions The diagnosis of paragonimiasis is made by identifying characteristic eggs in sputum or stool or identifying worms in biopsied tissue Multiple examinations and concentration techniques may be needed Serologic tests may be helpful; an ELISA available from the CDC has sensitivity and specificity

The four major tapeworms that cause noninvasive infections in humans are the beef tapeworm Taenia saginata, the pork

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