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The text color, as a color index (as returned by imagecolorallocate(), for example) The full path to the font (.ttf) file on your server s hard disk The string of text to draw

Tip You can use the value to clarify a format that should be followed when entering information. For example, you could set the value of a date to dd/mm/yy so that users know how to format the date.

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evaluated at t = t c . The assumption in the Levenberg-Marquardt method is that during the iteration process the matrix X T C - l X may become singular or nearly singular. By Theorem C.4, this must be a consequence of the N x K matrix X becoming singular or nearly so. It will be shown in this subsection that this possible singularity is cured by minimizing (6.147) under the equality constraint

(1.117)

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These constraints include factors such as the retinal locus of stimulation, the angular subtense, and the luminance level. In addition, the two stimuli must be viewed with identical surrounds, backgrounds, size, shape, surface characteristics, illumination geometry, etc. If any of the above constraints are violated, it is likely that the color match will no longer hold. However, in many practical applications, the constraints necessary for successful color-match prediction using simple tristimulus colorimetry cannot be met. It is these applications that require colorimetry to be enhanced to include the in uences of these variables. Such enhancements are color appearance models. The various phenomena that break the simple XYZ tristimulus system are the topics of the following sections of this chapter. Figure 6.1 illustrates a simple example of one color appearance phenomenon: simultaneous contrast, or induction. In Figure 6.1(a), the two gray patches with identical XYZ tristimulus values match in color since they are viewed under identical conditions (both on the same gray background). If one of the gray patches is placed on a white background and the other on a black background as in Figure 6.1(b), the two patches no longer match in appearance, but their tristimulus values remain equal. Since the constraint that the stimuli are viewed in identical conditions is violated in Figure 6.1(b), tristimulus colorimetry can no longer predict a match. Instead, a model that includes the effect of background luminance factor on the appearance of the patches would be required.

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If the tool palette is collapsed when the mouse cursor is not over it, right-click its title bar and choose Auto-Hide to uncheck this item.

MR (ER): Identi cation and description of site change and updated batch record Noti cation of site change Stability Application/ compendial requirements plus multipoint dissolution pro les in three other media (e.g., water, 0.1 N HCl, and USP buffer media at pH 4.5 and 6.8) until 80% of drug released or an asymptote is reached Apply some statistical test (f2 test) for comparing dissolution pro les No biostudy MR (DR): Identi cation and description of site change, and updated batch record Noti cation of site change Stability Application/ compendial requirements plus multipoint dissolution pro les in additional buffer stage testing (e.g., USP buffer media at pH 4.5 7.5) under standard and increased agitation conditions until 80% of drug released or an asymptote is reached Apply some statistical test (f2 test) for comparing dissolution pro les No biostudy Noti cation of site change Updated batch record Case B dissolution as for excipient change (level II) Stability No biostudy Noti cation of site change Updated batch record Application/compendial (pro le) requirements (as for level II) Stability Biostudy or ivivc IR: Identi cation and description of site change and updated batch record Noti cation of site change Stability Application/ compendial requirements No biostudy Prior approval supplement (accelerated stability data) for MR and changes being effected supplement for IR Annual report

Here s the code for the text editor. Save it as text_editor.php in your document root folder:

At the first sight, this is the best linear unbiased estimator. However, since the elements of C are generally functions of 8, the elements of C in (5.280) depend on i, making this

Direction of arrival [Deg]

(6.142)

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