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collection of integrated, subject-oriented databases designed to support the decisionmaking functions, where each unit of data is relevant to some moment in time and locality Large data warehouse may own several specialized warehouses, often called data marts However, neither data warehouses nor data marts makes decisions, they are only for the repository of data The process of DM, on the other hand, studies models, summaries, and derived values within a given collection of data in the data warehouse and data marts So DM is not simply a collection of isolated tools; it uses the tools to make a decision In practice, it is an iterative process, although a single and simple application of a method may not suf ce to achieve the mining goal DM focuses on the entire process of knowledge discovery, including data cleansing, learning, and integration and visualization of results.



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There are two categories of data mining: predictive DM and descriptive DM The former is to produce the model of the system described by the given data set, and the latter is to develop new, nontrivial information based on the available data The data mining process consists of the following steps: 1 State the problem and formulate the hypothesis 2 Collect the data 3 Preprocessing the data including segmentation; detection and removal, scaling, encoding and selecting features 4 Estimate the model 5 Interpret and validate the model and draw conclusion Some data mining tools are machine learning, statistics, and visualization; they are applied to data in the data warehouses and data marts for knowledge discovery In particular, some statistical methods are cluster analysis, decision trees and decision rules, association rules, arti cial neural network, genetic algorithms, fuzzy Inference systems, and N-dimensional visualization methods.





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These methods are standard techniques taught and used in computer science and statistical methods curricula 20432 An Example of Discovering the Average Hand Image In 25, we will discuss a CAD method is used to assess the bone age of a child from a hand radiographic image In the process we need to nd the average hand image of a child of a subgroup of given race, age, and gender from a large normal database comprising of children hand image data of different races from age 1 to 18 years old, both female and male Let us use this example to illustrate the concept of using data mining to nd the average hand image from a children radiographic hand image database following the DM ve-step process described in the aforementioned paragraph: 1 State the problem: To nd the average hand image 2.

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Collect the data: The normal children hand radiographic image database 3 Preprocessing the data: Each hand has over 20 quantitative parameters extracted from the image by image processing methods These parameters are used as the gauge to determine the average hand image in a subgroup in the hand database (see 25 for methods)..

(20.1)

146 Janimak, J J, and Marteleur, M (2004), On the stability of cerium oxide glass for terminal radiation sterilization, Rad Phys Chem 71, 195 198 147 DeGrazio, F L (2005), Parenteral packaging concerns for drugs: Early understanding of drug to package compatibility lowers the cost in the long run GEN: Genetic Eng News (Bioprocess Channel), 25(21), 2 148 DeGrazio, F L (2005), Parenteral packaging concerns for drugs: Early understanding of drug to package compatibility lowers the cost in the long run GEN: Genetic Eng News (Bioprocess Channel), 25(21), 2 149 Romacker, M (2005), Pre lled syringes: Why new developments are important in injectable delivery today, in Roessling, G, Ed, Pre lled Sringes: Innovations That Meet the Growing Demand, ONdrugDelivery, Sussex, United Kingdom 150 Wang, W, Wang, Y J, and Kelner, D N (2003), Coagulation factor VIII: Strucuture and stability, Int J Pharm.

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regarded as reacting suprafacially if the stereochemical fate at each end is the same, that is, the con guration is retained or inverted at each end. A s component is regarded as reacting antarafacially if the stereochemical fate at the two ends is di erent, that is, the con guration is retained at one end and inverted at the other, or vice versa. If one end of the bond is a hydrogen atom, that end is considered to react with retention of con guration. The stereochemical mode of reaction of that bond is then determined by whether con guration at the other end is retained s or inverted a .

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