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Another option, not yet implemented, is to connect the venous sources and arterial sinks by differential equations that model the pulmonary and systemic circulations, so as to provide an even more natural setting for the model heart and to enable the study of the in uence of the circulation on the function of the heart For further details concerning the construction of the model heart, see Ref [7], and for the mathematics underlying the construction of the aortic and pulmonic valves of the model, see Refs [49, 50] Although the anatomy of the model heart is realistic in many respects, there is considerable room for improvement, and indeed we have recently completed the construction of a next-generation version of the model in which cardiac computed tomography data are used during the construction process.

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We expect that the computational methods described in this chapter will produce even more realistic results when applied in the context of this more anatomically realistic next-generation heart model In Figures 73 and 74, we provide illustrative results obtained from the application of the parallel and adaptive version of the immersed boundary method described in this chapter to the simulation of a complete cardiac cycle In this computation, the physical domain is described as a periodic box that has a length of 26118 cm on each side (For comparison, note that the circumference of the human mitral valve ring is approximately 10 cm and its diameter is approximately 32 cm.

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) The locally re ned Cartesian grid consists of two levels, a global coarse level with 32 grid cells in each coordinate direction and a locally re ned ne level with a re nement ratio of 4 The timestep size is speci ed to ensure that the CFL number never exceeds C = 01, so that it suf ces to regrid the patch hierarchy every 10 timesteps To demonstrate the potential of our adaptive scheme to reduce the computational resources required to simulate cardiac uid dynamics, we also performed the rst 100 timesteps of this simulation with both uniform and locally re ned Cartesian grids.

1 0.8 0.6

In particular, we compare the performance of the adaptive immersed boundary method in three cases: (1) a uniform 1283 Cartesian grid, (2) a two-level locally re ned Cartesian grid with a coarse grid resolution of 643 and a re nement ratio of 2, and (3) a two-level locally re ned Cartesian grid with a coarse grid resolution of 323 and a re nement ratio of 4 Note that in all the cases, the grid spacing on the nest level of the hierarchy corresponds to that of a uniform grid with 128 grid cells in each coordinate direction These computations were performed on the Multiprogrammatic and Institutional Computing Capability Resource (MCR) at Lawrence Livermore National Laboratory, which is equipped with 1152 compute nodes, each consisting of two Intel 24 GHz Pentium 4 Xeon processors and 4 GB of memory..

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