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I d like to acknowledge the many people who contributed their talents to make this book possible: To Tim Green, my acquisitions editor at McGraw-Hill: Please tell me, as I have to know: is there or is there not a Mike voodoo doll in your home, and if so, have you used it Every time I tried to stop typing, my back started to hurt and I know you ve been to Jamaica No other explanation makes sense To my in-house Editor-in-Chief, Scott Jernigan: Sorry to take you away from the mighty Tsarion so much Level 80 is just around the corner Oh, and we re done now, so just go buy the MINI To Chris Crayton, technical editor: As far as I m concerned, I ve found my permanent tech editor Now to the bigger question: Do you want the job To Alec Fehl, contributing author: Alec, I truly appreciate you taking the time to go outside the job, catching errors and challenging me on concept Never again will I confuse The Two Auth s To Bill McManus, copy editor: You, sir, are the fastest, most accurate copyeditor I ve ever seen Like scary fast One of these days you have got to tell me your secret To Michael Smyer, Total Seminars resident tech guru and photographer: You ve learned the secret: good technology research means clear concepts, delivered in nice, tidy thought boxes I am content To Ford Pierson, graphics maven and editor: See! I told you it was fun You did such a great job that I m going to add a full eight feet to your chain Plus I m personally going to warm your gruel You ve earned it! To Dudley Lehmer, my partner at Total Seminars: Thanks for keeping things running smoothly so we had time to put together another great book To Meghan Riley, acquisitions coordinator at McGraw-Hill: What do you mean, We need that manuscript today! HAHAHAHA! You crack us up! To Laura Stone and Jody McKenzie, project editors: You truly fulfill the axiom: Speak quietly, but carry a big stick You almost can t see any bruises on me anymore Thank you both so much for your skill, patience, and perseverance! It was a joy to work with you again To Vastavikta Sharma, project manager: Thanks for making the book beautiful to behold To the ITC production team: Thank you for producing a marvelous book that I m proud to call my own.



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As a prophylactic drug for bipolar affective disorder, lithium significantly decreases the frequency and severity of both manic and depressive attacks in about 70% of patients A positive response is more predictable if the patient has a low frequency of episodes (no more than two per year with intervals free of psychopathology) A positive response occurs

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more frequently in individuals who have blood relatives with a diagnosis of manic or hypomanic attacks Patients who swing rapidly back and forth between manic and depressive attacks (at least four cycles per year) usually respond poorly to lithium prophylaxis initially, but some improve with continued long-term treatment Carbamazepine (see below) has been used with success in this group In addition to its use in manic states, lithium is sometimes useful in the prophylaxis of recurrent unipolar depressions (perhaps undiagnosed bipolar disorder) Lithium may ameliorate nonspecific aggressive behaviors and dyscontrol syndromes The dosages are the same as used in bipolar disorder Most patients with bipolar disease can be managed long-term with lithium alone, although some will require continued or intermittent use of a neuroleptic, antidepressant, or carbamazepine An excellent resource for information is the Lithium Information Center, Madison Institute of Medicine, 7617 Mineral Point Road, Suite 300, Madison, WI 53717-1914, http://wwwmimincorg/aboutlithinfoctrhtml Before treatment, the clinical workup should include a medical history and physical examination; complete blood count; T4, thyroid-stimulating hormone, blood urea nitrogen (BUN), serum creatinine, and serum electrolyte determinations; urinalysis; and electrocardiography in patients over age 45 or with a history of cardiac disease 1 Dosage Lithium carbonate is generally prescribed in the 300 mg unit In a small minority of patients, a slow release form or units of different dosage may be required Lithium citrate is available as a syrup The dosage is that required to maintain blood levels in the therapeutic range For acute attacks, this ranges from 1 to 15 mEq/L Although there is controversy about the optimal long-term maintenance dose, many clinicians reduce the acute level to 06 1 mEq/L in order to reduce side effects The dose required to meet this need will vary in different individuals For acute mania, doses of 1200 1800 mg/d are generally recommended Augmentation of antidepressants is usually achieved with half of these doses Once-a-day dosage is acceptable, but most patients have less nausea when they take the drug in divided doses with meals Lithium is readily absorbed, with peak serum levels occurring within 1 3 hours and complete absorption in 8 hours Half of the total body lithium is excreted in 18 24 hours (95% in the urine) Blood for lithium levels should be drawn 12 hours after the last dose Serum levels should be measured 5 7 days after initiation of treatment and changes in dose For maintenance treatment, lithium levels should be monitored initially every 1 2 months but may be measured every 6 12 months in stable, long-term patients Levels should be monitored more closely when there is any condition that causes volume depletion (eg, diarrhea, dehydration, use of diuretics) 2 Side effects Mild gastrointestinal symptoms (take lithium with food), fine tremors (treat with propranolol, 20 60 mg/d orally, only if persistent), slight muscle weakness, and some degree of somnolence are early side effects that are usually transient Moderate polyuria (reduced renal responsiveness to ADH) and polydipsia (associated with increased plasma renin concentration) are often present Potassium administration can blunt this effect, as may once-daily dosing of lithium Weight gain (often a result of calories in fluids.

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