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both these renin inhibitors share features reminiscent of small peptides such as the recurrence of amide functions (C5 5ONH) along the backbone. As noted in 2, some of the work that led to the development of small-molecule renin directly aided development of a new class of drugs for treating HIV/AIDS patients. Yet another example of the discovery of a new class of drugs that emerged from the search for new ways in which to treat high blood pressure had its origin in the treatment of asthma, a seemingly quite unrelated disease. It has been known for the better part of a century that the natural product purine base, theophylline, relaxes the constricted bronchioles during asthmatic attacks. The discovery of the role of the phosphodiesterase enzyme (PDE) by Sutherland in the early 1960s helped explain how this drug worked.53 He and his colleagues had found that a large number of physiological responses were controlled at the cellular level by molecules based on the purine adenosine. The process, simpli ed, involves the reversible conversion of the esteri ed form adenosine phosphate (AMP) to cyclized AMP (cAMP). This process, they found is mediated by PDE. Cleavage of the phosphate ester in cAMP by PDE reverses the signal and results in relaxation of involuntary muscle. The development of more delicate assays led to the nding that PDE, like many other messenger molecules, exists as many subtypes. There are recognized at present at least eleven PDEs, each with its own specialized target. It should not come as a surprise that this class of enzymes came under scrutiny as a source of



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See requirements in section 10.1.1. Current thresholds:

Job descriptions also form the basis for a sound (read: defensible) wage and salary structure But what if the payroll department is already a functioning entity What if a new payroll department is not being created, but a long-standing department needs to be revamped The suggestions discussed here can be applied to any payroll department The only adjustment needed when recon guring an existing department is to take the experience of the current staff into consideration when organizing the jobs and tasks (d) Writing Procedure Manuals It is discussed throughout this book and it bears repeating: the ef cient payroll department has written procedures for each job or task it performs Writing procedures for a payroll department is an arduous and time consuming task But it must be done in order for the department to function at peak ef ciency.





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where [Z0 ] represents the characteristic impedance matrix of the Floquet modes (diagonal). The first element zinp is the characteristic impedance of the input trans0 mission line with which the probe is attached. Typically its value is 50 . The GSMs of the probe layer and the patch layers are then combined to obtain the overall GSM of the probe-fed array.

signi cant unspeci ed and unanticipated events, a more effective crisis management strategy will make it effective and ef cient to devote less time to contingency planning for speci ed and anticipated events. This view connects with the concern to develop general responses discussed earlier in Example 8.2. If we accept crisis in the sense de ned above as something we must be prepared to manage, it follows that a disaster in the sense of a crisis we fail to manage effectively is something we need to be prepared to respond to. At the very least there may be legal liability issues.

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used through an interactive example on the code site, or downloaded and installed or modified as you see fit (thanks to its open-source license). Treemap analyzes multiple data points using the treemap visual data display method of nested, colored boxes. Treemap Visualizer makes identifying winners and losers among large sets of data easy and fun. Download it from www. analyticsformarketers.com/s/treemap.

Written procedures ensure that each task is done completely, accurately, and in the same manner each time it is performed This enables the payroll department to perform each task correctly and consistently no matter how many times or who performs the duty This is especially true in large departments, however, even single person departments can bene t from written procedures In addition, written procedures are helpful in training new or.

58. In our gateway example the constructor of MQ_Scheduler initializes the Activation_List and uses the Thread_Manager wrapper facade (47) to spawn a new thread of control: 59. 60. 61. requests. 62. this); 63. } Thread_Manager::instance ()->spawn (&svc_run, MQ_Scheduler::MQ_Scheduler (size_t high_water_mark): act_queue_ (high_water_mark) { // Spawn separate thread to dispatch method

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